口腔义齿打磨钛合金粉尘致鼠肺纤维化研究  

Effects of titanic alloy denture milling dust on fibrosis in lung of rats

作　　者：张织英[1] 李松英[2] 宋志芳[3] 

机构地区：[1]浙江大学医学院附属口腔医院修复科,杭州310006 [2]浙江大学医学院附属口腔医院病理科,杭州310006 [3]浙江大学医学院公共卫生系劳动卫生教研室,杭州310006

出　　处：《口腔医学》2005年第5期280-281,共2页Stomatology

基　　金：浙江省教育厅基金资助项目(491060G20163);浙江省医药卫生科学研究基金资助项目(2002ZX015)

摘　　要：目的研究钛合金义齿打磨粉尘致鼠肺纤维化作用。方法采用大鼠非暴露式气管内注入染尘,染尘后1个月处死动物,取肺组织作病理切片观察,血清铜蓝蛋白测定以及羟脯氨酸含量测定。结果染钛合金粉尘大鼠(20 g/L和10 g/L钛合金组)的血清铜蓝蛋白和羟脯氨酸测定结果与对照组相比差异均有显著性,病理切片显示各实验组大鼠肺组织内均有轻度纤维化改变,其程度与染尘剂量一致。结论钛合金义齿打磨粉尘可致大鼠肺轻度纤维化。Objective To study the effects of titanic alloy denture milling dust on lung fibrosis in rats. Methods Dust of titanic alloy was injected intratracheally. The rats were killed after one month and the lung tissue was drawn for observing pathological changes. The contents of ceruloplasmin and hydroxypmline were also measured. Result The contents of ceruloplasmin and hydroxypmline are significantly different between the experimental group and control group, Lung tissue fibrosis was demonstrated in some degree. Conclusion The titanic alloy denture milling dust affects the lung fibrosis of rats.

关 键 词：粉尘 肺纤维化 大鼠 

分 类 号：R135.2[医药卫生—劳动卫生]