儿童肺炎链球菌对β-内酰胺类、大环内酯类和氟喹诺酮类抗菌药物敏感性研究  

Resistance of Streptococcus Pneumoniae to β-lactams Macrolides and Fluoroquinolone among Children

作　　者：王咏红[1] 佟月娟[1] 俞桑洁[1] 杨永弘[1] 

机构地区：[1]首都医科大学附属北京儿童医院儿科研究所微生物室

出　　处：《首都医科大学学报》2005年第5期517-520,共4页Journal of Capital Medical University

基　　金：国家自然科学基金(30070793);北京市科委基金(Y0204004040131)资助项目

摘　　要：目的了解2002-2004年北京儿童医院门诊5岁以下呼吸道感染儿童鼻咽拭子中分离出的肺炎链球菌,对β-内酰胺类、大环内酯类和氟喹诺酮类抗菌药物的耐药性.方法使用E试验法(E-test)对114株肺炎链球菌进行抗菌药物的敏感性试验.结果114株肺炎链球菌对青霉素不敏感率为36%,对阿莫西林/棒酸全部敏感,对头孢菌素中头孢曲松不敏感率为6.1%,头孢呋辛为30.7%,头孢克洛为29%,大环内酯类耐药率在90%左右,全部菌株对氟喹诺酮类敏感.结论儿童肺炎链球菌对青霉素和头孢二代抗菌药物不敏感率为29%～36%,对大环内酯类耐药在90%左右,未发现对氟喹诺酮类耐药菌株.Objective To investigate resistance to β-1actams, macrolides and fluoroquinolone in carriage isolates of Streptococcus pneumoniae in nasopharynx among children under 5 with respiratory infection who attended a general outpatient department at Beijing Children＇s Hospital from 2002 to 2004. Methods Antimicrobials sensitivity testing of Streptococcus pneumoniae E-test methods and the results were analyzed according to NCCLS （2002）. Results Resistance of pneumococci to penicillin was 36%, amoxycillin/clavulanate was 0 % , ceftriaxone was 6.1% , cefaclor was 29 % , cefuroxime was 30.7 % , macrolides were around 90% , and fluoroquinolone were 0%. Conclusion Non-susceptible to penicillin and the second cephalosporin of Streptococcus pneumoniae isolates among children ranged from 29 % -36 % , and to macrolides were about 90 %.

关 键 词：肺炎链球菌 细菌耐药 氟喹诺酮类抗菌药物 

分 类 号：R378.12[医药卫生—病原生物学]