壳寡糖对小鼠微循环及移植性肿瘤的影响  

The effect of chitooligosaccharides on mouse microcirculation and transplantation tumor

作　　者：王海生[1] 范廷英[1] 任青华[2] 温晓燕[2] 王杰[2] 张博[2] 

机构地区：[1]山东大学第二医院,山东济南250033 [2]山东省医学科学院,山东济南250062

出　　处：《中国生化药物杂志》2005年第5期301-302,共2页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的探讨壳寡糖的作用机制。方法观察壳寡糖对小鼠耳廓小动脉的血流变化,对S180肉瘤的影响和对肝癌H22实体瘤的影响。结果壳寡糖能加快小鼠耳廓小动脉的血流速度,对S180肉瘤和肝癌H22实体瘤具有明显的抑制作用。结论壳寡糖对小鼠微循环和移植性肿瘤具有显著的影响。Purpose To discuss the mechanism of controlling tumor about chitooligosaccharides. Methods The effect of chitooligosaccharides on mouse microcireulation, the effect on S180 sarcoma and the effect on liver cancer H22 solid tumor were observed. Results Chitooligosaccharides could not only improve the blood flow rate of mouse obviousely, but also restrain S180 and liver cancer H22 solid tumor effectively. Conclusion Chitooligosaccharides can affect obviously the microcireulation and transplantation tumor of mouse.

关 键 词：壳寡糖 微循环 S180肉瘤 肝癌H22实体瘤 

分 类 号：R538[医药卫生—内科学]