浸蜡石墨电极伏安法测定抗癌药物盐酸阿霉素  

Voltammetric Determination of Doxorubicin Hydrochloride With Wax-Impregnated Graphite Electrode

作　　者：杨志洁[1] 刘盛辉[2] 叶建农[2] 方禹之[2] 

机构地区：[1]云南大理师范高等专科学校化学系,大理671000 [2]华东师范大学化学系,上海200062

出　　处：《分析化学》1996年第4期471-474,共4页Chinese Journal of Analytical Chemistry

摘　　要：本文用自制浸蜡光谱纯石墨电极伏安法测定盐酸阿霉素。在PH=6.0的磷酸缓冲溶液体系中，盐酸阿霉素在5．0×10-8mol／L～1．0×10-6mol／L范围内浓度与电流呈线性，检测限可达1．0×10-8mol／L。方法选择性好，抗干扰能力强，不需样品分离可直接进行测定，结果令人满意。Voltammetric determination of doxorubicin hydrochloride with wax-impregnated spectrographic pure graphite electrode was described. Various conditions for the determination of doxorubicin hydrochIoride were studied. The peak current is proportional to the concentration of doxorubicin hydrochloride within 5. 0×10-8mol/L^1.0×10-6mol/L. The detection limit is 1.0×10-8mol/L. For ten paralIel measurements, the relative standard deviation is 2. 2%. The method is fairly free of interference and the determination results are satisfactory.

关 键 词：石墨电极 伏安法 盐酸阿霉素 抗癌药物 

分 类 号：R979.1[医药卫生—药品] O657.14[医药卫生—药学]