甲状腺激素与瘦素分泌关系的探讨  

Study on the Relationship Between Serum Levels of Leptin Thyroid Hormones

作　　者：刘平安[1] 翟春桃[1] 袁素芬[1] 

机构地区：[1]上海第二医科大学附属第九人民医院核医学科,200011

出　　处：《放射免疫学杂志》2005年第5期330-331,共2页Journal of Radioimmanology

摘　　要：目的:探讨甲状腺功能与瘦素分泌的关系。方法:正常甲状腺功能组75例、甲状腺功能亢进组44例、甲状腺功能减退组27例,分别检测血清甲状腺功能指标和瘦素浓度。结果:甲状腺功能正常组、甲状腺功能亢进组和甲状腺功能减退组的血清瘦素浓度分别为(5.40±3.78)ng/ml、(5.99±5.24)ng/ml和(5.59±4.23)ng/ml,三组瘦素浓度无明显差别。血清瘦素浓度与TSH浓度呈正相关(r=0.27,P<0.01)。结论:甲状腺功能状态对瘦素分泌无明显影响,瘦素浓度与TSH有正相关关系。Objective To evaluate the relationship between serum levels of leptin and thyroid functional status. Methods Serum leptin （with RIA） and pituitary. - thyroid axis hormones （with CLIA） were measured in 75 euthyroid controls, 44 hyperthyroid subjects and 27 hypothyroid subjects. Results The levels of leptin in euthyroid controls, hyperthyroid subjects and hypothyroid subjectswere （ 5.40 ± 3.78 ） ng/ml, （ 5.99 ± 5.24 ） ng/ml and （ 5.59 ± 4.23 ） ng/ml respectively with no significant differences among them. The serum leptin levels were positively correlated with serum TSH levels （ r = 0. 27, P 〈 0.01 ）. Conclusion Thyroid function has no effect on serum leptin levels and TSH levels correlates closely with those of serum leptin.

关 键 词：甲状腺激素 瘦素 甲状腺激素 瘦素分泌 甲状腺功能亢进 血清瘦素浓度 甲状腺功能减退 甲状腺功能状态 正常甲状腺 功能指标 正相关 

分 类 号：R541.61[医药卫生—心血管疾病] R714.147[医药卫生—内科学]