AMI患者治疗前后血NO/NOS和ET检测的临床意义  

Clinical Significance of Measurement of Changes in Serum NO/NOS Ratio and Plasma ET Content After Treatment in Patients with Acute Myocardial Infarction (AMI)

作　　者：董昭书 刘徐桂 

机构地区：[1]江苏省赣榆县人民医院,222100

出　　处：《放射免疫学杂志》2005年第5期337-338,共2页Journal of Radioimmanology

摘　　要：目的:探讨了急性心肌梗死(AMI)患者治疗前后血NO/NOS和ET含量的变化。方法:应用酶法和放免法检测了30例AMI患者血NO/NOS和ET的含量,并与35名正常健康人作比较。结果:AMI患者治疗前血NO水平显著地低于正常人组(P<0.01),而NOS和ET又非常显著地高于正常人组(P<0.01),经治疗后一个月血NO、NOS与正常人比较无显著性差异(P>0.05),而ET与正常人比较仍有显著性差异(P<0.05)。结论:检测AMI患者血NO/NOS和ET水平对临床观察预后有重要的价值。Objective To study the clinical significance of changes of plasma ET and serum NO/NOS ratio in patients with AMI after treatment. Methods Serum NO/NOS ratio （ with EIA） and plasma ET （ with RIA） contents were measured in 30 patients with acute myocardial infarction both before and after treatment as well as in 35 controls. Results Serum levels of NO were significantly lower （P 〈 0.01 ） in patients with acute myocardial infarction, but serum NOS and plasma ET levels were significantly higher （P 〈 0. 01 ） than those in the controls before treatment. One months after treatment the serum levels of NO and NOS in the patients were not much different from those in the controls （P 〉 0.05 ）, hut plasma ET levels remained significantly higher （P 〈 0.05 ）. Conclusion Changes of serum NO/NOS ratio and plasma ET contents after treatment might be of prognostic importance in patients with acute myocardial infarction.

关 键 词：急性心肌梗死 一氧化氮 一氧化氮酶 内皮素 急性心肌梗死(AMI) NO/NOS 放免法检测 ET水平 治疗前后 血NO 患者 临床意义 显著性差异 

分 类 号：R542.22[医药卫生—心血管疾病] R446.61[医药卫生—内科学]