老年慢性支气管炎患者治疗前后血清SOD、TNF、CRP和T淋巴细胞亚群检测的临床意义  

Clinical Significance of Determination of Changes of Serum SOD,TNF,CRP Levels and T-cell Subsets Distribution Type After Treatment in Aged Patients with Chronic Bronchitis

作　　者：郑宏[1] 

机构地区：[1]江苏省连云港市第一人民医院,222002

出　　处：《放射免疫学杂志》2005年第5期342-344,共3页Journal of Radioimmanology

摘　　要：目的:探讨了老年慢性支气管炎患者治疗前后血清SOD、TNF、CRP和T淋巴细胞亚群分布状况的改变。方法:应用放免法、化学法和单克隆抗体法对42例老年慢性支气管炎患者进行了治疗前后血清SOD、TNF、CRP和T淋巴细胞亚群的检测,并以35名正常健康人作比较。结果:老年慢性支气管炎患者在治疗前血清SOD、T淋巴细胞CD4/CD8值水平低于正常人组(P<0.01),而CRP、TNF水平则明显地高于正常人组(P<0.01),经治疗后15d,除CRP水平与正常人比较无差异外,SOD、CD4/CD8、TNF水平仍与正常人组比较有显著性差异(P<0.05)。结论:检测老年慢性支气管炎患者血清SOD、TNF、CRP和T淋巴细胞亚群的水平对了解病情、观察治疗效果均具有十分重要的临床价值。Objective To investigate the changes of serum SOD, TNF, CRP levels and T - cell subsets distribution type after treatment in aged patients with chronic bronchitis. Methods Serum SOD, TNF levels （ with RIA）, CRP levels （ with bio - chemistry） and T - cell subsets distribution type （with monoclonal antibody） were detected both before and after treatment in 42 aged patients with chronic bronctitis as well as in 35 controls. Results Before treatment, the serum levels of SOD, CD4/CD8 ratios were significantly lower and serum TNF, CRP levels significantly higher in the patients than those in the controls （P 〈0. O1 ）. After treatment, with the exception of CRP levels, the SOD,TNF levels and CDJCDs ratios remained significantly higher than those in controls （P 〈0.05 ）. Conclusion Determination of serum SOD, TNF, CRP levels and T - cell subsets distribution type is clinically meaningful in aged patients with chronic bronchitis.

关 键 词：老年慢性支气管炎 超氧化物歧化酶 肿瘤坏死因子 C反应蛋白 T淋巴细胞亚群 T淋巴细胞亚群 支气管炎患者 TNF水平 血清SOD 老年慢性 治疗前后 CRP 临床意义 检测 

分 类 号：R563.1[医药卫生—呼吸系统] R562.2[医药卫生—内科学]