过敏性紫癜患儿外周血红细胞免疫功能的变化与TNF-α水平的相关性研究  

Study on the Relationship Between Peripheral Blood Red Blood Cells Immunofunction Status and Serum TNF-α Levels in Pediatric Patients with Henoch-Schnlein Purpura

作　　者：冯越[1] 何浩明[1] 

机构地区：[1]江苏省连云港市第一人民医院,222002

出　　处：《放射免疫学杂志》2005年第5期344-345,共2页Journal of Radioimmanology

摘　　要：目的:探讨过敏性紫癜患儿外周血红细胞免疫功能的变化及其与TNF-α水平的相关性。方法:应用免疫法测定31例过敏性紫癜患儿的红细胞免疫功能,放免法测定TNF-α含量,并与正常健康儿童作比较。结果:过敏性紫癜患儿RBC-C3bRR水平明显降低(P<0.01),而TNF-α水平显著升高(P<0.01);RBC-C3bRR水平与TNF-α水平呈明显的负相关(r=-0.3018,P<0.05)RBC-ICRRR水平明显高于正常人组(P<0.01),与TNF-α水平呈正相关,(r=0.3588,P<0.05)。结论:过敏性紫癜患儿存在血红细胞免疫调节的紊乱,免疫功能的低下与TNF-α水平有相关性。Objective To investigate the relationship between changes of peripheral RBC immuno - function and serum TNF - α levels in pediatric patients with Henoch - Schoenlein purpura. Methods RBC immuno - function status was studied with immunologic methods and serum TNF - α levels were measured with RIA in 31 pediatric patients with Henoch - Schoenlein purpura and 35 controls. Results Levels of RBC - C3bRR were significantly lower and levels of serum TNF - α were significantly higher in the patients than those in controls （P 〈 0.01 ）. These two variables were significantly negatively correlated （r = -0. 3018, P 〈 0.05 ）. On the contrary, the RBC -ICRRR levels were significantly higher in the patients （P 〈0.01 ） and were positively correlated with levels of TNF- α （ r = 0. 3588, P 〈 0.05 ）. Conclusion There were disturbances of RBC immuno - regulation with suppressed immuno - function in the purpura patients, which were related to the high levels of TNF - α.

关 键 词：过敏性紫癜 红细胞 免疫功能 肿瘤坏死因子 红细胞免疫功能 TNF-Α 过敏性紫癜 外周血 患儿 RBC-C3BRR 水 细胞免疫调节 免疫法测定 

分 类 号：R285.5[医药卫生—中药学] R725.546[医药卫生—中医学]