肺癌患者手术治疗前后血清NO/NOS、CEA和SIL-2R含量的临床意义  

Clinical Significance of Determination of Changes of Serum NO/NOS, CEA and SIL-2R Levels After Operation in Patients with Lung Cancer

作　　者：陈慧玉[1] 

机构地区：[1]江苏省连云港市第一人民医院外科,222002

出　　处：《放射免疫学杂志》2005年第5期346-347,共2页Journal of Radioimmanology

摘　　要：目的:探讨了肺癌患者手术治疗前后血清NO/NOS、CEA和SIL-2R水平及临床意义。方法:分别应用放免法、化学法和ELISA测定了31例肺癌患者手术治疗前后血清NO/NOS、CEA和SIL-2R含量,并与35名正常健康人作比较。结果:肺癌患者手术治疗前后血清NO/NOS、CEA和SIL-2R水平非常显著地高于正常人组(P<0.01),而NO水平则低于正常人组(P<0.01),治疗后三个月,则与正常人比较无显著差异(P>0.05)。结论:检测肺癌患者手术治疗前后血清NO/NOS、CEA和SIL-2R含量的变化与患者的病情和预后密切相关,具有重要的临床价值。Objective To study the clinial significance of changes of serum NO/NOS, CEA and SIL - 2R levels after operation in patients with lung cancer. Methods Serum CEA （with RIA） ,NO/NOS （with biochemistry） and SIL -2R （with ELISA） levels were determined in 31 patients with lung cancer both before and after operation as well as in 35 controls. Results Before operation, the serum NOS,CEA,SIL-2R levels were significantly higher than those in controls （P 〈0.01 ） while serum NO levels were significandy lower than those in controls （P 〈0.01 ）. Three months after operation the levels in patients were not much different from those in controls （P 〉 0.05 ）. Conclusion Serum NO/NOS, CEA and SIL- 2R levels were closely related to the disease process of lung cancer and were of prognostic values.

关 键 词：肺癌 一氧化氮 一氧化氮合酶 癌胚抗原 白细胞介素-2受体 SIL-2R水平 NO/NOS 肺癌患者 临床意义 后血清 治疗前 CEA 手术 含量 

分 类 号：R737.9[医药卫生—肿瘤] R446.61[医药卫生—临床医学]