力平脂治疗不稳定性心绞痛及对血尿酸的影响  

The Treatment of Unstable Angina with Finofibrate and the Change of Serum Uric Acid

作　　者：张伟强[1] 姜丽萍[1] 潘宝安[1] 

机构地区：[1]潍坊医学院附属潍坊市人民医院,山东潍坊261041

出　　处：《潍坊医学院学报》2005年第5期337-338,共2页Acta Academiae Medicinae Weifang

摘　　要：目的观察力平脂对冠心病不稳定性心绞痛(UA)的疗效及对血尿酸(SUA)的影响。方法80例UA患者随机分为力平脂加常规治疗组(治疗组)和常规治疗组(对照组),疗程为8周,治疗前后观察两组患者临床症状,心电图缺血变化及SUA浓度的改变。结果①治疗后治疗组、对照组心绞痛每周发作次数分别为1.4±1.5次和3.7±3.2次,硝酸甘油日用量分别为0.3±0.2mg和0.9±0.4mg,治疗组较对照组疗效明显,差别有显著性(P<0.05);②治疗组症状疗效有效率为95%,对照组80%,治疗组心电图疗效有效率为67.5%,对照组有效率为42,5%,两组差别均有显著性(P<0,05);③治疗组治疗后,SUA为299.5±45.8μml/L,较治疗前明显降低(P<0.01),对照组SUA治疗前后无明显变化。结论力平脂可降低UA患者的SUA浓度,调整血脂,进而改善UA患者临床症状及心电图缺血改变。Objective To investigate effect of the treatment of unstable angina with finofibrate and the change of serum uric acid（SUA）.Methods Eighty patients were diveded into treatment group（Group T：routine treatment＋finofibrate）and control group（Group C：routine treatment）at random.To compare the differneces of symptom,ECG and SUA prior to and 8 weeks after treatment.Results With regard to fits of angeina the times are 1.4±1.5 and 3.7± 3.2 in Group T and Group C respectively.The amount of itroglycerin daily is 0.3±0.2 and 0.9±0.4 in Group T and Group Crespectively （P〈0.05）.In terms of symptom and ECG effectively power is 95% （Group T）vs.80%（Group C）and 67.5%（Group T） vs.42.5%（Group C）respectively（P〈0.05）.SUA decreases 299.5±45.8μml/L（P〈0.05）in Group T and there is no significant change in Group C.Conclusion Finofibrate can decrease SUA ,relieve symptom and improve ECG of patient with unstable anginal.

关 键 词：力平脂 心绞痛 不稳定性 血尿酸 

分 类 号：R541.4[医药卫生—心血管疾病]