共轭二炔结构类脂化合物的合成及其聚合脂质体的制备和稳定性研究  

Synthesis of Diacetylenic Lipids and Studies on the Preparation and Stability of Polymerized Liposomes

作　　者：于凯[1] 孙彦[1] 张宝申[1] 周秀中[1] 

机构地区：[1]天津大学化工系,南开大学化学系

出　　处：《高等学校化学学报》1996年第3期392-395,共4页Chemical Journal of Chinese Universities

基　　金：国家教育委员会优秀年轻教师基金

摘　　要：合成了７种具有共轭二炔结构的单链类脂化合物，并将其分别制成聚合脂质体，考察了其在酸、碱、盐、缓冲液及乙醇等化学环境下的稳定性，结果表明二十五－１０，１２－二炔－１－醇磷脂乙醇胺的聚合脂质体稳定性最佳．The seven lipids with diacetylenic structure were synthesized,using lipids Ⅰ-Ⅶ polymerized liposomes were prepared,and their stabilitics under different environmental conditions(e.g.,alcohol,acid,alkaline,salt and buffer solutions)were investigated. The results indicated that the polymerized liposome prepared with pentacosa-10, 12-diyne-1-olphosphoryl ethanolamine exhibited an enhanced stabilities.

关 键 词：类脂化合物 聚合脂质体 稳定性 共轭二炔 

分 类 号：O633.14[理学—高分子化学]