N-(溴代-2-吡咯甲酰基)氨基酸甲酯的合成  

Synthesis of N-(Methoxycarbonylalkyl)bromopyrrole-2-carboamides

作　　者：曾向潮[1] 徐石海[1] 李毅群[1] 刘珀润[1] 李玉霞[1] 

机构地区：[1]暨南大学化学系,广州510632

出　　处：《有机化学》2005年第11期1420-1426,共7页Chinese Journal of Organic Chemistry

基　　金：国家863计划(No.2004AA628030);广东省科技计划(No.2004B30101011)资助项目.

摘　　要：在室温条件下,2-三氯乙酰基吡咯经溴代反应,再与氨基酸甲酯反应得到一系列N-(溴代-2-吡咯甲酰基)氨基酸甲酯,收率为64.8%～92.2%.通过元素分析,1HNMR,IR和MS对产物结构进行了表征,培养了N-(1-甲基-4,5-二溴-2-吡咯甲酰基)甘氨酸甲酯的单晶并进行单晶X射线衍射分析.初步活性试验表明,目标产物对金黄色葡萄球菌、粪链球菌等五种细菌有一定的抑制作用.A series of N-（methoxycarbonylalkyl）bromopyrrole-2-carboamides were synthesized by acylation of amino acid methyl esters with bromo-2-trichloroacetylpyrroles at room temperature in 64.8%-92.2% yields. The structures of products were determined on the basis of ^1H NMR, IR, MS spectra and elemental analyses. One of these products was analyzed by single crystal X-ray diffraction. Preliminary antibiotic tests showed that some target compounds inhibit the five bacteria such as Staphylococcus aureus and Streptococcus faecalis.

关 键 词：N-(溴代-2-吡比咯甲酰基)氨基酸甲酯 酰基化反应 溴化反应 合成 抑菌活性 氨基酸甲酯 溴代反应 甲酰基 吡咯 单晶X射线衍射分析 

分 类 号：O626.32[理学—有机化学]