微波辐射催化合成乙酰水杨酸  

Synthesis of acetylsalicylic acid by microwave irradiation under the assistance of sodium bicarbonate catalyst

作　　者：李西安[1] 李丕高[1] 贺宝宝[1] 李苗[1] 

机构地区：[1]延安大学化学与化工学院,陕西延安716000

出　　处：《延安大学学报（自然科学版）》2005年第3期49-50,85,共3页Journal of Yan'an University：Natural Science Edition

摘　　要：在微波辐射下以碳酸氢钠为催化剂合成乙酰水杨酸,考察了影响反应的主要因素,实验结果表明合成最佳工艺条件为n(水杨酸)∶n(乙酸酐)=1∶2.0,微波功率为微波炉“中低”档(40%)151W,辐射时间45 s,催化剂用量为水杨酸质量的2%,产率可达96.9%(重结晶产率可达92.1%)。Aspirin was synthesized by microwave radiation, using salicylic acid and acetic anhydride as raw materials and anhydrous sodium bicarbonate as a catalyst. The optimal condition aspirin was synthesized by molar ratio of salicylic acid to acetic acid anhydride was 1： 2. 0, the time of radiation was 45s, the weight of anhydrous sodium bicarbonate was 2% of salicylic acid ,The yield was over 92. 1%, The method was of characteristic of easy operation control and high yield.

关 键 词：微波辐射 水杨酸 乙酸酐 乙酰水杨酸 合成 

分 类 号：O621.53[理学—有机化学] O621.3[理学—化学]