促进剂对马来酸噻吗洛尔经皮渗透的影响  

The Effect of Enhancers on the Timolol Transdermal Therapeutic System

作　　者：冀学芳[1] 平其能[1] 刘国杰[1] 周轶[1] 

机构地区：[1]中国药科大学药剂学教研室,北京市药品检验所

出　　处：《中国药科大学学报》1996年第1期6-9,共4页Journal of China Pharmaceutical University

摘　　要：建立了马来酸噻吗洛尔体外离体经皮释放检测方法，筛选了几种典型渗透促进剂：月桂氮酮（Ａｚｏｎｅ）、１，２－丙二醇、油酸、α－吡咯烷酮，对促进剂的选择、配伍、配比、作用浓度及作用部位进行了研究，确定了Ａｚｏｎｅ与１，２－丙二醇以１：３的比例配伍，Ａｚｏｎｅ在马来酸噻吗洛尔膜剂中作用的最佳浓度为３％，Ａｚｏｎｅ与１，２－丙二醇的作用部位在角质层。A reliable method with UV was developed for the determination of timolo permeation through rat skin in vitro. The results of timolo permeation tests showed that the effects of enhancers were ordered as follows: Azone>Oleic acid>1, 2-Propylene glycol>α-Pyrrolidone>no enhancer,the mixed enhancers(Azone+1,2-Propylene glycol, oleic acid+1, 2-propylene glycol)can obviously accelerate the penetration coefficient of timolol,the appropriated proportion of azone and 1,2-propylene glycol was 1:3 and the main position exhibiting promoting of Azone and 1,2-propylene glycol was in stratum corneum.

关 键 词：马来酸噻吗洛尔 渗透促进剂 

分 类 号：R972.4[医药卫生—药品] R944.9[医药卫生—药学]