女性单纯性肥胖与内分泌激素的相关性研究  

Changes of Endocrine Hormones in Simple Obese Females

作　　者：魏涛[1] 陈艳萍[2] 段文若[1] 马永秀[1] 

机构地区：[1]青岛市市立医院放免中心,山东青岛266011 [2]青岛市妇女儿童医疗保健中心检验科,山东青岛266011

出　　处：《标记免疫分析与临床》2005年第3期141-145,共5页Labeled Immunoassays and Clinical Medicine

摘　　要：探讨女性单纯性肥胖患者血液中瘦素(leptin)、脂联素(adiponectin)、胰岛素(insulin)、皮质醇(cortisol)、醛固酮(aldosterone)等水平的变化及与肥胖程度(BMI)的变化关系、相关关系及其对肥胖的调节,为女性单纯性肥胖患者的临床早期干预和有效防治提供理论依据.研究对象分为:女性肥胖前期患者〈BMI范围23～24.9kg/m2〉48例,肥胖者〈BMI≥25kg/m2〉40例,对照组〈BMI范围18～22.9kg/m2〉42例.用放射免疫法(RIA)测定血浆瘦素、脂联素、胰岛素、醛固酮水平,用免疫放射分析法(IRMA)测定血浆皮质醇水平,各变量之间的关系先进行相关分析,然后用直线回归和多元线性回归分析.结果显示,肥胖前期组和肥胖组血清瘦素、胰岛素、皮质醇、醛固酮水平均明显高于对照组(P＜0.01),且各变量值之间呈密切相关;血清脂联素水平则明显低于对照组.其中,血清水平变化与BMI呈直线正相关的激素为:瘦素(P=0.0001)、胰岛素(P=0.0034)、皮质醇(P=0.0469)、醛固酮(P=0.0001),均随着BMI升高而升高;与BMI呈直线负相关的激素有脂联素(P=0.0001),随着BMI升高而降低.在各种激素的相关关系中,瘦素、脂联素的变化与其他激素有明显相关.结论:激素间的互相作用使'瘦素-胰岛素'平衡、'胰岛素-脂联素'调节、'瘦素-胰岛素'调节等反馈环自身适应性调节,当机体体重大量病理性增加后,其机体内分泌体系为减少体内能量的蓄积作出适应性调节,这会改变各种平衡环的相互间动态平衡,为糖尿病、肾病、高血压等病的发生发展提供了条件.To study the relationship between plasma leptin, adiponectin, insulin, cortisol, aldosterone and BMI in simple obese females, leptin, adiponectin, insulin, cortisol and aldosterone were tested in 48 fat women with BMI ranging 23-24. 9kg/m^2 and another 40 with BMI≥ 25kg/m^2 by radioimmunoassay and immunoradiometric assay. Besides, 42 healthy women（BMI ranging 18-22.9kg/m^2）were also tested as controls. Pearson＇s correlation and other statistic methods were used in data processing. The results showed that the levels of leptin, insulin, cortisol and aldosterone were linearily postively correlated with BMI in obesity groups, and were higher than those in controls remarkably （P〈0.01）. Meanwhile, the levels of adiponectin were linearily nagatively correlated with BMI in obesity groups. Our conclusion is that along with increase of BMI, the plasma levels of insulin and leptin increase in obese women, whereas the level of adiponectin decreases. The increasing levels of leptin, insulin, cortisol, aldosterone and decreasing level of adiponectin may be partly indicative of the etiology of diabetes, hypertension and nephrosis in obese females.

关 键 词：女性 单纯性肥胖 瘦素 脂联素 胰岛素 皮质醇 醛固酮 内分泌激素 

分 类 号：R589.2[医药卫生—内分泌]