皮肤扩张囊对甲硝唑和普鲁卡因渗透性的研究  

EXPERIMENTAL STUDY ON PERMEABILITY OF SKIN EXPANDERS TO METRONIDAZOLE AND PROCAINE

作　　者：展望[1,2] 鲁开化[1,2] 艾玉峰[1,2] 王纪保[1,2] 

机构地区：[1]安徽医科大学附属第一医院整形外科 [2]第四军医大学西京医院整形外科中心

出　　处：《中国修复重建外科杂志》1996年第1期32-34,共3页Chinese Journal of Reparative and Reconstructive Surgery

摘　　要：皮肤扩张术已逐渐用于临床，但植入扩张器后产生的疼痛及感染妨碍了这项技术的广泛应用。采用２０只国产肾形扩张囊进行体外实验，分别在囊内注入甲硝唑和普鲁卡因，观察到扩张囊有渗透性。药物注入扩张囊后的最初２～４小时渗出较快。渗透性大小与药物分子量有关，分子量愈小，渗透性愈大。研究结果表明：注水扩张过程中，在扩张囊内注入一定量的甲硝唑，通过渗透可在扩张囊周围形成有效药物浓度，达到预防和控制感染的目的。注入普鲁卡因，通过渗透作用，可缓解扩张过程出现的疼痛。An in vitro experiment showed that the skin expanders were permeable to metronidazole and procaine. Twenty kidney shaped skin expanders were divided into four groups. Group 1. 100ml 0.2% metronidazole solution was injected into the expanders and the expenders were immersed in a flask filled with 100ml saline solution, and then were placed in a hermetically sealed glass chamber; Group 2.the whole procedure was the same as that of Group 1 except the expander was previously boiled in water for 30 minutes; Group 3. 100 ml 2% procaine was injected instead of metronidazole, other step was the same as that of group I; and Group 4. the whole procedure was the same as that of Group 2 except the solution injected was 2% procaine. The concentration of metronidazole and procaine in the surrounding saline was measured at 1st, 2nd, 4th, 16th, 24th, 48th, 72nd 120th hours. The rate of diffusion of a drug was highest at 2 and 4 hous. The rate of diffusion was inversely proportional to its molecular weight, i.e., the smaller the molecular weight the greater the permeability. In view of this, during the process of expansion, metronidazole and procaine would diffuse out of the expander which might be beneficial for preventing infection and controlling pain.

关 键 词：皮肤扩张囊 药物渗透 甲硝唑 普鲁卡因 

分 类 号：R622[医药卫生—整形外科] R978.61[医药卫生—外科学]