聪灵胶囊对小鼠软脑膜微循环障碍的改善作用  

Effect of Congling Capsule on Mice Cerebral Pial Microcirculation

作　　者：黄新武[1] 肖顺汉[1] 李万平[1] 李晓冰[1] 张红[1] 

机构地区：[1]泸州医学院药学院药理教研室,四川泸州646000

出　　处：《中国微循环》2005年第5期330-332,共3页Journal of Chinese Microcirculation

摘　　要：目的观察聪灵胶囊对小鼠软脑膜微循环障碍的改善作用。方法将60只小鼠随机分为聪灵胶囊大、中、小剂量组、阳性对照组和正常对照组,分别于灌胃给药10 d后,开颅窗观察小鼠软脑膜微循环,然后在软脑膜局部滴加去甲肾上腺素复制微循环障碍模型,观察微循环障碍时小鼠软脑膜微循环。结果聪灵胶囊各剂量组均可改善去甲肾上腺素所致的小鼠软脑膜局部微循环障碍,使微动脉扩张,血流增快,每视野交织网点数增多,对血流流态也有一定的改善作用,使血色变红。9 m in后聪灵胶囊各剂量组软脑膜局部微循环障碍基本恢复,而空白对照组恢复不明显。结论聪灵胶囊能改善小鼠软脑膜微循环。Objective To observe the effect of Congling Capsule（CLC） on mice cerebral pial microcirculation. Methods The effect of CLC on mice cerebral pial microcireulation was observed under normal state and microcirculation disturbance state was established by means of dripping noradrenaline on the cerebral pial. Results CLC dilated peripheral artery of cerebral pial microcireulation and increased capillary network point number and accelerated the rate of blood flow of microcirculation. Besides, the blood is redder. Conclusion CLC can improve mice cerebral pial microcireulation.

关 键 词：聪灵胶囊 软脑膜微循环 小鼠 

分 类 号：R331.35[医药卫生—人体生理学]