他克莫司联合白藜芦醇对同种异体心脏移植术后T细胞亚群及免疫功能的影响  

Effect of FK506 combinated with resveratrol on T-cell subsets and its immune function following homologous heart transplantation

作　　者：郑奇军[1] 蔡振杰[1] 俞世强[1] 王晓武[1] 程亮[1] 胡军[1] 

机构地区：[1]第四军医大学西京医院心脏外科,陕西西安710033

出　　处：《中国现代医学杂志》2005年第20期3099-3101,共3页China Journal of Modern Medicine

摘　　要：目的研究他克莫司(FK506)联合白藜芦醇(resveratrol,Res)对同种异体心脏移植术后急性排异反应的抑制作用。方法采用大鼠异体异位移植模型,将心脏移植于腹部。术后分别进行不同免疫治疗,于移植术后第7d检测外周血T细胞亚群分布和血清IL-2含量,同时观察心脏移植术后移植心脏的病理改变。实验分单纯应用FK506组、单纯应用Res组以及联合应用FK506和Res组,以异体异位移植术后不用药为对照组。结果单独用药组与不用药对照组比较,移植心脏病理改变明显减轻,联合用药组又明显轻于单独用药组。各用药组外周血CD4+T淋巴细胞明显低于未用药组。结论FK506和Res都可以通过抑制CD4+T淋巴细胞增殖而阻止或延缓同种异体心脏移植的急性排异反应。FK506与Res联用具有协同作用,可更有效地产生免疫抑制作用。[Objective] To investigate the preventive effects of FK506 combinated with resveratrol on acute rejection following homologous heart transplantation. [Methods] Donor＇s heart derived from rat was transplanted into the abdomen cavity of another rat, On the 7th day after transplantation, CD4^＋, CD8^＋T-cell subsets and IL-2 were examined, and graft＇s pathological changes were observed. The recipients were randomly divided into mono-FK506 thempy group, mono-resveratrol therapy group and combination-therapy group, the un-treatment group as control. [Results] Compared with un-treatrnent group, graft＇s pathological changes were signifieandy prolonged in mono-thempy group; Corobination-therapy of FK506 with resveratrol could significantly prolong the survival of xen-graft heart when compared with FK506 or resveratrol used alone. The number of CD4CF-cell and level of IL-2 in mono-therapy group and comblnation-therapy group were much less than in un-treatment group. [Conclusion] Both FK506 and resveratrol can suppress proliferation of CD4^＋F-cell and expression level of IL-2, so they can prevent or delay acute rejection.

关 键 词：心脏移植 免疫抑制 急性排异反应 治疗 

分 类 号：R392.4[医药卫生—免疫学]