尿毒症血液透析患者脂质代谢的临床研究  

Clinical studies of lipid parameters in hemodialysis patient

作　　者：周盾[1] 王悦[2] 孙洞箫[1] 贾艳秋[1] 吴军[1] 

机构地区：[1]锦州医学院附属第一医院泌尿内科,辽宁锦州121001 [2]辽宁省锦州市中心医院泌尿内科,辽宁锦州121001

出　　处：《中国现代医学杂志》2005年第20期3140-3141,3144,共3页China Journal of Modern Medicine

摘　　要：目的探讨尿毒症血液透析患者脂质代谢的变化。方法选择35例无明显出血倾向的尿毒症患者进行为期1a的临床观察,于透前分别按个体剂量给予普通肝素动脉血路端注射,并在透析前、透析后6个月及12个月检测血脂、脂蛋白、载脂蛋白水平及脂酶活性。结果治疗组透析前血甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-c)、极低密度脂蛋白胆固醇(VLDL-c)、脂蛋白(Lp)(a)和载脂蛋白B(apo-B)水平均升高,而高密度脂蛋白胆固醇(HDL-c)、载脂蛋白A1(apo-A1)水平较对照组低(P<0.05)。结论尿毒症血液透析患者存在脂质代谢障碍,易合并心脑血管疾病。[Objective] To investigate the effect of lipid parameters in hemodialysis patients. [Methods] The 35 pre-dialysis patients were investigate for one year. The level of serum lipid, lipoprotein, apolipoprotein were measured at months 0, 6 and 12 of trial. [Results] Significant increases in serum concentrations ofTG, LDL, VLDL, Lp （a） and apo-B were increased, whereas serum concentrations of HDL, apo-A1 were decreased before hemodialysis. [Conclusion] There are lipid metabolize obstacle in hemodialysis patients. They tends to suffer from heart and brain blood vessel disease

关 键 词：血液透析 脂质 

分 类 号：R692.5[医药卫生—泌尿科学]