快速减压对兔血气、电解质和肺病理的影响  

Effects of rapid decompression on blood-gas,electrolyte and lung pathology in rabbits

作　　者：高光凯[1] 石永亮[1] 吴镝[1] 杨鹰[1] 王淑新[1] 鲍新平[1] 

机构地区：[1]解放军第四○一医院全军航海病医学专科中心,青岛266071

出　　处：《中华航海医学与高气压医学杂志》2005年第3期139-141,共3页Chinese Journal of Nautical Medicine and Hyperbaric Medicine

基　　金：全军医药卫生科研基金"十五"课题(01MA056)

摘　　要：目的探讨快速减压对兔动脉血气、电解质和肺病理改变的影响。方法将14只实验兔放入加压舱中,于5min内用压缩空气加压至0.6MPa,停留60min,然后于3～5min内减至常压。分别于进舱前、出舱后3h和3d,进行动脉血气、电解质和肺病理检查。结果(1)快速减压可造成兔动脉血氧分压(PaO2)、氧饱和度(SaO2)和二氧化碳分压(PaCO2)下降;红细胞压积(Hct)升高。(2)快速减压可造成兔肺泡壁充血、肺泡腔内渗出,肺毛细血管内气泡形成。结论(1)快速减压可造成家兔动脉血气改变和血液浓缩。(2)肺毛细血管内气泡可能是引起动脉血气改变和血液浓缩的原因。Objective To investigate the effects of rapid decompression on bloed-gas analysis, electrolyte and lung pathology in rabbits. Methods 14 rabbits were put into the hyperbaric chamber, and the pressure was increased to 0.6 MPa within 5 min, using compressed air. 0.6 MPa was maintained for 60 rain, and then was decompressed to normal pressure within 3 ～ 5 min. Arterial blood-gas analysis, electrolyte and lung pathology in rabbits were examined before compression, 3 h and 3 d after decompression respectively. Results （1） PaO2, SaO2 and PaCO2 were decreased after rapid decompression, but hematocrit was increased. （2）Alveolar wall congestion, alveolar infiltration and gas bubbles in pulmonary capillary were observed in lung. Conclusions （ 1 ） Arterial blood-gas and hematocrit changes could be induced by rapid decompression. （2） Gas bubbles in pulmonary capillary may be the cause of arterial blood-gas changes.

关 键 词：减压病 血气分析 电解质 家兔 肺病理改变 快速减压 动脉血气 实验兔 动脉血氧分压 二氧化碳分压 

分 类 号：R84[医药卫生—航空、航天与航海医学] R85[医药卫生—临床医学]