白及不同提取部位对家兔血小板聚集的影响  

Effects of Different Extracts from Bletilla Colloid on Rabbit Platelet Aggregation

作　　者：陆波[1] 徐亚敏[1] 张汉明[2] 李铁军[2] 邱彦[2] 

机构地区：[1]中国人民解放军第411医院药剂科,上海200081 [2]中国人民解放军第二军医大学药学院,上海200433

出　　处：《解放军药学学报》2005年第5期330-332,共3页Pharmaceutical Journal of Chinese People's Liberation Army

基　　金：上海市科学技术委员会的资助;No.024119031

摘　　要：目的探讨白及不同提取部位对家兔血小板聚集的影响。方法比浊法测定血小板聚集率。结果白及正丁醇提取部位和水溶性部位可显著升高腺苷二磷酸(ADP)诱导的血小板最大聚集率,而乙酸乙酯提取部位可显著抑制ADP诱导的血小板聚集,石油醚提取部位对ADP诱导的血小板聚集无显著影响。各提取部位对血小板数无显著影响。结论白及正丁醇提取部位和水溶性部位是白及止血作用的主要有效部位,其止血作用与其促进血小板聚集作用有关。Aim To study the Effects of different extracts from Bletilla colloid on rabbit platelet aggregation. Methods The platelet aggregation rate was measured by turbidimetric method. Results n-Butanol extract and water extract significantly enhanced and petroleum ether extract from Bletilla colloid prominently reduced platelet maximum aggregation induced by ADP, while acetic ether extract had no effect. Conclusion n-Butanol extract and water extract from Bletilla colloid is major active extracts playing a part in hemostasis. The hemostasis effect is related to promoting platelet aggregation.

关 键 词：白及 提取物 血小板聚集 腺苷二磷酸 ADP 

分 类 号：R973.1[医药卫生—药品]