绝经后妇女血清瘦素水平与骨代谢的关系  

Relationship between serum leptin concentrations and bone metabolism in postmenopausal women

作　　者：张彤[1] 李万根[2] 

机构地区：[1]广州医学院第一附属医院内分泌科,510120 [2]广州医学院第二附属医院内分泌科

出　　处：《中国骨质疏松杂志》2005年第3期317-318,共2页Chinese Journal of Osteoporosis

基　　金：广东省自然科学基金资助项目(000333)

摘　　要：目的探讨绝经后妇女血清瘦素水平与骨代谢的关系。方法测定85例绝经妇女血清瘦素水平及体重指数、体脂量、甘油三脂和总胆固醇,用双能X线法测定股骨和腰椎的骨密度,并测定骨钙素及尿钙水平,分析瘦素与上述指标之间的相关性。结果用骨密度与瘦素及瘦素相关指标进行多元逐步回归分析,瘦素没有进入腰椎和股骨颈骨密度方程;瘦素与骨钙素及尿钙水平也均无相关。结论瘦素与绝经后妇女的骨代谢无直接关系。Objective To investigate the relationship between leptin concentrations and bone metabolism in postmenopausal women. Methods Eighty-five postmenopausal women were included. The levels of leptin, osteocalcin and urine calcium/creatine were measured and bone mineral density （BMD） were assayed by linear stepwise regression. Results Statistical analysis showed that leptin was neither related to the BMD of spine and femoral, nor the levels of osteocalcin or calcium/creastine. Conclusions Leptin has no direct effect on bone metabolism in postmenopausal women.

关 键 词：骨质疏松 骨密度 瘦素 骨钙素 血清瘦素水平 绝经后妇女 骨代谢 股骨颈骨密度 多元逐步回归分析 体重指数 绝经妇女 总胆固醇 甘油三脂 

分 类 号：R512.6[医药卫生—内科学] R681[医药卫生—临床医学]