Enantioseparation of Racemic Anti-hepatitis New Drug Bicyclol with Crystallization  

作　　者：Wei HU Yan LI Chun Zhen ZHANG 

机构地区：[1]Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050

出　　处：《Chinese Chemical Letters》2005年第11期1471-1473,共3页中国化学快报（英文版）

摘　　要：The enantioseparation of anti-hepatitis new drug （±）-bicyclol was performed by optically active alkaloid. The alcoholic acid, the hydrolysate of bicyclol was reacted with optically active alkaloid, such as brucine, strychnine, quinidine etc., the diastereoisomeric salts were obtained by fractional recrystallization, then separately decomposed and esterified to obtain the two enantiomers of bicyclol. The pharmacological study showed that the effect of （-）-bicyclol was more potent than racemic bicyclol two times and the potency of （＋）-bicyclol was incative.The enantioseparation of anti-hepatitis new drug （±）-bicyclol was performed by optically active alkaloid. The alcoholic acid, the hydrolysate of bicyclol was reacted with optically active alkaloid, such as brucine, strychnine, quinidine etc., the diastereoisomeric salts were obtained by fractional recrystallization, then separately decomposed and esterified to obtain the two enantiomers of bicyclol. The pharmacological study showed that the effect of （-）-bicyclol was more potent than racemic bicyclol two times and the potency of （＋）-bicyclol was incative.

关 键 词：（±）-Bicyclol 4 4＇-dimethoxy-2 3 2 3＇-bis（methylenedioxy）-6-hydroxymethyl-6＇-methoxy-carbonyl biphenyl anti-hepatitis resolution. 

分 类 号：TQ465[化学工程—制药化工]