血管紧张素原及血管紧张素Ⅱ1型受体基因多态性与冠心病的关系  

The relationship between coronery heart disease and polymorphism of angiotensiongen and angiotensin II type 1 receptor genes

作　　者：贾永平[1] 任洁[2] 吕吉元[1] 郭晓红[1] 

机构地区：[1]山西医科大学第一医院心内科 [2]太原市中心医院

出　　处：《中国心血管病研究》2005年第11期816-819,共4页Chinese Journal of Cardiovascular Research

基　　金：山西省自然科学基金赞助(20021111)

摘　　要：目的研究血管紧张素原(AGT)基因M235T及血管紧张素Ⅱ1型受体(ATIR)基因A1166/C多态性与冠心病的关系。方法应用多聚酶链反应结合限制性内切酶法(PCR-RFLP)对100名经冠脉造影确诊为冠心病(CHD)的患者和52名冠造结果正常及18名门诊常规体检且无冠心病史者基因多态性进行分析。结果冠心病(CHD)组TT基因型和T等位基因频率显著高于对照组(分别为0.67、0.79和0.44、0.63,P<0.05),而C等位基因频率在两组中差异则无统计学意义(分别为0.075和0.064,P>0.05)。结论AGT基因变异与CHD发病具有相关性。提示T等位基因可能是CHD的危险因素,而AT1R基因A1166/C多态性与冠心病则无关联。Objective To study the relationship between coronary heart disease and polymorphism of angiotensiongen gene （AGT） M235T and angiotensin Ⅱ type 1 receptor gene （AT1R） Al166/C. Methods Polymerase chain reaction combined with restriction enzyme digestion was used to analyse gene polymorphism in 100 patients with CHD identified by coronary angiography and 70 control subjects that was composed of 52 cases with normal results of coronary angiography and 18 healthy subjects without clinical evidence of CHD. Results The frequency of Tr gene type and T allele in patients is signifieiently higher than in controls （0.67, 0.79 vs 0.44, 0.63 respectively）. However, there is no difference in C allele frequency between two groups （0.075 vs 0.064）. Conclusion There is an association between gene variants of the angiotensinogen and the incidence of CHD.T allele is a risk factor, which carries 2.059 times risk of CHD. No significant association between A1166/C polymorphism of AT1R gene and CHD is confirmed in this study.

关 键 词：血管紧张素原 血管紧张素Ⅱ 基因 冠状动脉疾病 

分 类 号：R641.4[医药卫生—外科学]