纳米羟基磷灰石人工骨的毒性与细胞相容性实验研究  

Study on toxicity and cytocompatibility of nano-hydroxyapatite artificial bone

作　　者：江捍平[1] 王大平[1] 阮建明[2] 朱伟民[1] 

机构地区：[1]广东深圳市急救医疗中心,广东深圳518035 [2]中南大学冶金粉末国家重点实验室,湖南长沙410083

出　　处：《中国医学工程》2005年第5期458-461,共4页China Medical Engineering

基　　金：深圳市科技计划项目资助(200304219)

摘　　要：目的评价纳米羟基磷灰石人工骨的毒性与细胞相容性相容性,从而为运用于骨缺损修复提供有关安全性的数据和资料。方法对新型纳米羟基磷灰石人工骨进行亚急毒性试验、抑菌试验、热原试验、细胞毒性试验、溶血试验等试验。结果此纳米羟基磷灰石人工骨材料无毒,无抑菌作用,不引起溶血,不含致热原物质。[Objective] To evaluate the toxicity and cytocompatibility of the nano-hydroxyapatite artificial bone （nano-HA） for the clinical use of bone＇s reconstruction. [Method] To text the toxicity and cytoeompatibility through the experiments on subacute systemic toxicity, bacteriostasis, pyrogen, cytotoxicity, and haemolysis. [Results] All the results indicate that the material has no toxicity, no bacteriostasis, no cytotoxicity, no haemolytic activit and do not the contain the pyrogen material. [Conclusion] The nano- hydroxyapatite （nano-HA） artificial bone obtains excellent safety and cytocompatibility .

关 键 词：羟基磷灰石 纳米材料 人工骨 毒性 细胞相容性 

分 类 号：R318.17[医药卫生—生物医学工程]