雌-孕激素治疗绝经后妇女高胆固醇血症的临床研究  

Clinical study of treatment of postmenopausal hypercholesteremia with estrogen and progestogen

作　　者：高瑞萍[1] 张珍[1] 黄惠芳[2] 黄英源[2] 李东东[1] 

机构地区：[1]广东药学院妇产科教研室,广东广州510240 [2]广州市红十字会医院妇产科,广东广州510220

出　　处：《广东药学院学报》2005年第5期605-606,共2页Academic Journal of Guangdong College of Pharmacy

摘　　要：目的探讨绝经后高胆固醇血症妇女用雌-孕激素治疗后血中脂蛋白及性激素水平的变化。方法选取符合条件的绝经后高胆固醇血症妇女52例,给予妊马雌酮0.625 mg/d,安宫黄体酮(MPA)4 mg/d治疗。于治疗前及治疗后3个月、6个月测定空腹血脂、性激素及身高体重,计算体重指数(BM I)。结果49例患者按计划完成疗程,治疗后3个月、6个月与治疗前比较,血中高密度脂蛋白(HDL-C)显著升高(P<0.05),低密度脂蛋白(LDL-C)显著下降(P<0.05),总胆固醇(TC)有所下降,但差异无显著性(P>0.05),三酰甘油(TG)有所升高,但在正常范围,差异无显著性(P>0.05)。结论雌-孕激素对绝经后高胆固醇血症妇女脂代谢产生有益的影响。Objective to explore the variations of lipoproteins and sex hormones after treatment with estrogen and progestogen. Methods 52 women with hypercholesteremia after menopause was treated with 0. 625 mg/d Premarin （ conjugated estrogens） and 4 mg/d medroxyprogesterone acetate （MPA）. Lipoprotein under fasting state, sex hormone levels, body weight and body height were measured, and body weight index （ BMI ） were calculated before treatment, and three months and six months after treatment. Results 49 patients completed the whole treatment course as planned, compared with pretreatment lipoprotein levels, HDL-C increased significantly （P 〈 0. 05） , LDL-C decreased significantly, total cholesterol （ TC ） decreased with no statistic significance （ P 〉 0.05 ） , and triglyceride （TG） increased with no statistic significance and the variations of triglyceride is within the normal range. Conclusion estrogen and progestogen treatment may benefit to the treatment of postmenopausal hypercholesteremia.

关 键 词：性激素 绝经 高胆固醇血症 脂蛋白 妇女 

分 类 号：R589.2[医药卫生—内分泌]