3,3-二甲氧基丙腈的合成  

Synthesis of 3,3-Dimethoxypropanenitrile

作　　者：郝宝玉[1] 俞迪虎[1] 陈新志[1] 蒋建权[1] 

机构地区：[1]浙江大学材料与化工学院,杭州310027

出　　处：《染料与染色》2005年第5期41-42,共2页Dyestuffs and Coloration

摘　　要：以2—氯—3—苯硫砜基丙腈[Ⅰ]为原料经过消除和加成二步反应合成3,3—二甲氧基丙腈[Ⅱ]。[Ⅰ]在0℃～20℃脱HCl得3—苯硫砜基丙烯[Ⅲ],收率为88%。[Ⅲ]在甲醇溶液中以甲醇钠为催化剂反应得[Ⅱ],收率98%。消除反应的创新处在于用四氢呋喃代替乙醚,节省大量溶剂,收率有所提高,加成反应的创新处是增大甲醇钠的投料比,优化反应条件。3,3-DimethoxypropaneniWile was synthesized from 2-chloro-3-phenylsulfonylpropanenitrile by elimination and addition reactions. 3-phenylsulfonylpropanenitrile was obtained by eliminating HCI from 2-chloro-3-phenylsulfonylpropanenitrile at 0-20~C with a yield of 88%. 3-Phenylsulfonylpropanenitrile was reacted with sodium methoxide in methanol, giving 3,3-dimethoxypropanenitrile with a yield of 98%. Elimination reaction was innovated by using THF as a solvent instead of ethyl ether and addition reaction was innovated by using an excess of sodium methoxide in methanol, so as to have the reaction condition optimized,

关 键 词：2-氯-3-苯硫砜基丙腈 3 3-二甲氧基丙腈 3-苯硫矾基丙烯腈 

分 类 号：TQ226.61[化学工程—有机化工]