硝矾散及其拆方对红色毛癣菌和须癣毛癣菌体外药敏作用研究  

Study on Medicine's sensibility of Xiaofan Powder with Disassemble the Prescription in vitro on Red Trichophytosis and Whisker Trichophytosis

作　　者：何定淑[1] 王淑美[1] 何淑惠[1] 陈伟海[1] 胡益勇[1] 

机构地区：[1]重庆医科大学中医药学院,重庆400050

出　　处：《实用中医药杂志》2005年第11期647-648,共2页Journal of Practical Traditional Chinese Medicine

摘　　要：目的:观察硝矾散及其拆方对红色毛癣菌、须癣毛癣菌的药敏作用。方法:将2%硝矾散及其拆方分为3组,另设克霉唑癣药水组。采用体外抑菌试验药基法检测4组对红色毛癣菌、须癣毛癣菌的最低抑菌浓度(M IC)。结果:各组对红色毛癣菌、须癣毛癣菌的M IC均值分别为:2%硝矾散组0.0718mg/m l、0.0670mg/m l,2%枯矾组0.1436mg/m l、0.2500mg/m l,2%芒硝组0.4061mg/m l、0.5359mg/m l,2%复方克霉唑癣药水组0.0670mg/m l、0.0769mg/m l。2%硝矾散复方效果优于拆方,有显著性差异(P<0.05);2%硝矾散抗红色毛癣菌、须癣毛癣菌作用与2%复方克霉唑癣药水无显著性差异(P>0.05)。结论:硝矾散及其拆方对红色毛癣菌、须癣毛癣菌均有抑制作用,复方作用优于拆方。Objective：To study the antifungal effect of Xiaofan Shan and its separated prescriptions on Trichophyton rubrum and Trichophyton mentagrophytes. Methods：2% of Xiaofan Shan, Kufan and Mangxiao were used to study their minimal inhibitory concentrations （MICs） for Trichophyton rubrum and Trichophyton mentagrophytes in vitro. Results ： Respectively, the MICs of each groups for Trichophyton rubrum and Trichophyton mentagrophytes,0. 0718mg/ml and 0. 0670mg/ml for 2% Xiaofan Shan,0. 1436mg/ml and 0. 2500mg/ml for 2% Kufan,0. 4061 mg/ml and 0. 5359mg/ml for 2% Mangxiao, in addition, the MICs of 2% Clotrimazole solution compound were 0. 0670mg/rnl and 0. 0769mg/ml. The results indicated that the antifungal effect of 2% of Xiaofan Shan was better than Kufan and Mangxiao groups （P 〈 0. 05 ）, there was no statistical difference in control groupe 2% Clotrimazole solution compound （P〉 0. 05 ）. Conclusion： Xiaofan Shan, kufan and Mangxiao can inhibit Trichophyton rubrum and Trichophyton mentagrophytes in vitro. The antifungal effect of Xiaofan shan was proved to be more effective than its separated prescriptions.

关 键 词：硝矾散及其拆方 药敏 红色毛癣菌 须癣毛癣菌 抗红色毛癣菌 须癣毛癣菌 体外抑菌试验 硝矾散 敏作用 拆方 克霉唑癣药水 显著性差异 最低抑菌浓度 

分 类 号：R978.5[医药卫生—药品] R756[医药卫生—药学]