环氧化物水解酶在手性催化中的研究进展  

Research Progress of Epoxide Hydrolase in Chiral Catalysis

作　　者：沈佳佳[1] 张晓军[2] 周晓云[1] 

机构地区：[1]浙江工业大学生物与环境工程学院,浙江杭州310004 [2]浙江工业大学生物制药研究所,浙江杭州310004

出　　处：《精细与专用化学品》2005年第22期6-9,共4页Fine and Specialty Chemicals

基　　金：浙江省自然基金资助项目(No.302067)

摘　　要：简要介绍环氧化物水解酶的研究进展。重点介绍环氧化物水解酶的结构特点和催化特性,即核心结构和帽子结构两个功能性结构及三位一体的催化活性构象。最后介绍环氧化物水解酶在生物催化等精细化学品领域中的应用,并展望其广阔的应用前景。Progresses in research work of epoxide hydrolase were briefly introduced. The characteristic of epoxide hydrolase structure and its catalysis performance were described emphatically, i.e. two functional structures： core structure and cap structure, and trinitarian catalytical activity conformation. Finally, the applications of epoxide hydrolase in fine chemicals fields used as biological catalysis and etc. were narrated, and its broad application prospect was viewed.

关 键 词：环氧化物 环氧化物水解酶 生物催化 光学活性 环氧化物水解酶 手性催化 精细化学品 子结构 催化特性 生物催化 活性构象 三位一体 应用 

分 类 号：O629.8[理学—有机化学]