α-溴-2,4-二氯苯乙酮合成研究  

Study on Synthesis of α-Bromo-2,4-dichloroacetophenone

作　　者：卢言建[1] 郑庚修[1] 许崇娟[1] 藏传论[1] 

机构地区：[1]济南大学化学化工学院,山东济南250022

出　　处：《精细与专用化学品》2005年第22期17-19,共3页Fine and Specialty Chemicals

摘　　要：在混合金属卤化物催化剂存在下,溴与2,4-二氯苯乙酮在混合溶剂中反应得到戊环唑、甲环唑、乙环唑、丙环唑中间体α-溴-2,4-二氯苯乙酮。最佳反应条件是:n(2,4-二氯苯乙酮)∶n(溴)=1∶1,溴滴加时间为1h,催化剂用量为1%(质量分数),混合溶剂,反应温度为20℃,此时产物纯度90·0%,收率达94·0%。The α-bromo-2,4-dichloroacetophenone, a key intermediate in synthesis of azaconazole, metaconazole, etaconazole and propiconazole was prepared by reacting bromine with 2,4-dichloroacetophenone in blended solvent in the presence of mixed metal halide catalyst. Experiments showed that the optimal reaction conditions were as follows： the ratio of 2,4-dichloroacetophenone to bromine was 1： 1, bromine was added dropwise into mixed solvent within lh, the dosage of catalyst was 1% （mass ratio）, and the temperature was 20℃. The purity of the final product was 90.0% and its yield was 94.0%.

关 键 词：丙环唑 α-溴-2 4-二氯苯乙酮 溴化 混合金属卤化物 二氯苯乙酮 合成研究 最佳反应条件 混合金属卤化物 溴 混合溶剂 质量分数 反应温度 催化剂 

分 类 号：O625.42[理学—有机化学]