洛伐他汀对慢性肾脏病患者尿白细胞介素-6的影响  

THE EFFECTS OF LOVASTATIN ON INTERLEUKIN-6 IN PATIENTS OF CHRONIC KIDNEY DISEASE

作　　者：宋海翔[1] 张荣振 王子芬[1] 李延国[3] 陈雯[3] 左振素[1] 

机构地区：[1]临沂市中医医院,山东临沂276002 [2]河东区芝麻墩医院 [3]临沂市人民医院

出　　处：《临沂医学专科学校学报》2005年第5期337-339,共3页Journal of Linyi Medical College

摘　　要：目的观察洛伐他汀对慢性肾脏病(CKD)患者尿白细胞介素-6(IL-6)的影响,探讨他汀类药物对肾脏的保护作用.方法将血脂正常的CKD患者89例随机分成两组,治疗组在综合治疗的基础上口服洛伐他汀(20～40mg/d),对照组维持综合治疗,疗程为6个月.观察治疗前后尿IL-6的变化.结果治疗组尿IL-6显著下降(P＜0.05),肾功能改善,血脂无明显变化;对照组各指标无明显变化.结论洛伐他汀有非降脂的肾保护作用,改善肾功能.Objective To explore the curative effects of lovastatin on urinary interleukin-6 （IL-6） in patients of chronic kidney disease （CKD）. 89cases of CKD with normal blood-lipid levels were randomly divided into two groups. The treatment group were treated with lavostation（20-40mg/d） in addition to the comprehensive treatment. The contrast group received comprehensive treatment only. The courses of treatment were 6 months in both groups. The changes of IL-6 before and after treatments were observed. MethodsResults The level of IL-6 in the treatment group delined significantly （P〈0.05）. The renal functions were improved greatly and no obvious changes in blood-lipid level were found, while the indexes in the contrast group remained unchanged. Conclusion Lovastatin can be used to protect and improve the renal functions.

关 键 词：洛伐他汀 慢性肾脏病 白细胞介素-6 

分 类 号：R692[医药卫生—泌尿科学]