牛繁缕的化学成分研究  

Studiy on Chemical Constituents of Malachium aquaticum (L.)Fries

作　　者：黄文哲[1] 李玉环[2] 张伟东[3] 周荣汉[1] 

机构地区：[1]中国药科大学,江苏南京210038 [2]中国医学科学院中国协和医科大学医药生物技术研究所,北京100050 [3]佳木斯大学,黑龙江佳木斯154013

出　　处：《现代中药研究与实践》2005年第5期27-28,共2页Research and Practice on Chinese Medicines

摘　　要：目的研究牛繁缕Malachium aquaticum(L.)Fries的化学成分。方法采用硅胶柱、SephadexLH-20柱、RP-C18反相柱色谱分离纯化,通过理化常数测定和光谱分析鉴定化合物的结构。结果从牛繁缕中分得5个化合物。根据波谱分析和理化数据,鉴定这5个化合物分别为β-谷甾醇(-βsitosterol,MA1)、芹菜素(apigenin,MA2)、胡萝卜苷(daucosterol,MA3)、牡荆苷(vitexin,MA4)和6-C-β-D-葡萄糖-8-C-β-D-半乳糖芹菜素(6-C--βD-glu-8-C--βD-gal-apigenin,MA5)。结论化合物MA5为首次从该植物中分离得到。Objective To study the chemical constituents of Malachium aquaticum. Methods The chemical constituents of the plant were isolated and purified by silicagel column ,Sephadex LH-20 column , RP-C18 column chromatography, and their structures were elucidated with physicochemical properties by spectroscopic analysis. Results Five compounds were obtained. They were determined as β-sitosterol （ MA1 ）, apigenin （ MA2 ）, daucosterol （ MA3 ）, vitexin （ MA4 ） and 6-C-β-D-glu-8-C-β-D-galapigenin （MA5） ,respectively. Conclusion The compound MA5 were isolated from the plant for the first time.

关 键 词：牛繁缕 黄酮 甾醇 

分 类 号：R284.1[医药卫生—中药学]