莫达非尼对军事飞行学员飞行工作能力和情感状态的影响  

Effects of modafinil on flight performance and mood states of military student pilots

作　　者：詹皓[1] 景百胜[1] 辛益妹[1] 李彤[1] 韦四煌[1] 唐桂香[1] 王海波[1] 郭华[1] 葛朝丽[1] 

机构地区：[1]空军航空医学研究所,北京100036

出　　处：《中华航空航天医学杂志》2005年第2期90-94,共5页Chinese Journal of Aerospace Medicine

基　　金：空军后勤科研计划项目(KH0108011)

摘　　要：目的观察莫达非尼对军事飞行学员飞行工作能力和情感状态的影响。方法21名男性飞行学员分两组:安慰剂组(n=10)和莫达非尼组(n=11)。在飞行前2h(10∶30)分别服用莫达非尼或安慰剂200mg。对飞行活动中的心电进行连续监测,完成飞行任务后由飞行教员对飞行操作能力进行评价。此外,比较两组飞行前后的基本生命体征、视反应时、临界闪光融合频率和主观嗜睡感、疲劳感以及情绪情感状态的变化。结果与安慰剂相比,服用莫达非尼对飞行操作、生命体征、视反应时、临界闪光融合频率等指标均无明显影响,但使飞行中心率明显增加(平均增加15.7%,P<0.01)、飞行后RPE量表的疲劳感积分明显降低(平均降低10%,P<0.05)、POMS量表的“有力好动”感积分明显升高(平均升高20%,P<0.05)。结论服用常规单剂量莫达非尼(200mg)对飞行工作能力无明显不良影响,并有明显提高机体应激反应能力、降低主观疲劳感的作用。Objective To investigate the effects of modafinil on flight performance and mood states of military student pilots. Methods Twenty-one male military pilot students were randomly divided into placebo group（n=10）and modafinil group（n=11）. Modafinil （200mg） or placebo was given at 10 ： 30 （2 h before flying）. The electrocardiogram was monitored during flying and flight performance was evaluated by instructors. In addition, the following parameters, including basic vital signs,visual reaction time, critical flicker fusion frequency（CFF）, scores of Stanford sleepiness scale （SSS）,rating of perceived exertion（RPE） and profile of mood states（POMS） were measured before and after flying. Results There were no significant differences of flight performance, basic vital signs,visual reaction time, CFF between the two groups. Compared with the placebo group, heart rate was significantly increased during flying（P〈0.01）,and scores of subjective fatigue feelings were remarkably decreased after flying in modafinil group （P 〈0.05）. Conclusions Modafinil given at routine, single dose（200mg） had no significant adverse effect on flight performance,and could significantly enhance the ability of stress reaction and lower the subjective fatigue level.

关 键 词：中枢神经系统药物 莫达非尼 飞行学员 认知 飞行工作能力 

分 类 号：R82[医药卫生—临床医学]