莫达非尼对人体基础+G_z耐力和科里奥利加速度耐力的影响  

Effects of modafinil on human basic +G_z tolerance and Coriolis acceleration tolerance

作　　者：詹皓[1] 耿喜臣[1] 谢溯江[1] 颜桂定[1] 贾宏博[1] 韦四皇[1] 景百胜[1] 

机构地区：[1]空军航空医学研究所,北京100036

出　　处：《中华航空航天医学杂志》2005年第2期95-97,共3页Chinese Journal of Aerospace Medicine

基　　金：空军后勤科研计划项目(KH0108011)

摘　　要：目的观察服用莫达非尼对人体基础+Gz耐力、科里奥利加速度耐力的影响,为飞行人员合理用药提供有关试验依据。方法7名健康青年男性志愿者为受试者,试验分两批:①受试者于8∶00～9∶00交叉服用莫达非尼和安慰剂200mg(相隔1周)后1h进行基础+Gz耐力测定,并在+Gz暴露前后测定受试者的血压和脉搏;②受试者于8∶00～9∶00交叉服用莫达非尼和安慰剂200mg(相隔1周)后1h进行科里奥利加速度耐力的检测。结果服用莫达非尼与安慰剂后1h,两组的基础+Gz耐力分别为3.86±0.24和3.79±0.27、科里奥利加速度耐力分别为25.57±11.67和30.56±10.25,莫达非尼与安慰剂间的观测指标均无明显差异。结论服用莫达非尼200mg起效后对人体基础+G耐力和抗运动病能力均无明显不良影响。Objective To observe the effects of modafinil on human basic ＋Gz tolerance and Coriolis acceleration tolerance. Methods Seven healthy young male volunteers served as subjects. The experiment was divided into two parts： ① subjects administered modafinil （200mg） or placebo at 8 ： 00～9 ： 00 a.m. alternatively with one week interval, and their basic ＋Gz tolerance was measured 1 h later. Blood pressure and pulse rate were obtained immediately before and after the G-tolerance test. ② subjects administered modafinil （200 mg）or placebo at 8 ： 00～9 ： 00 a.m. alternatively with one week interval, and their Coriolis acceleration tolerance was measured 1 h later. Results The G tolerance of modafinil group and control group was 3.86 ± 0.24 and 3.79 ±0.27 respectively; and their Coriolis acceleration tolerance was 25.57 ±11.67 and 30.56 ± 10. 25 separately. The differences between modafinil group and control group were both non-significant. Conclusions No significant adverse effects on human basic ＋ Gz tolerance and antimotion sickness ability were found 1 h after taking modafinil 200 mg.

关 键 词：莫达非尼 加速度 科里奥利加速度 身体耐力 

分 类 号：R85[医药卫生—航空、航天与航海医学]