硫普罗宁注射液治疗抗结核药物性肝损害的临床疗效观察  

Clinical efficacy of tiopronin in treating liver injury caused by anti-tuberculous drug

作　　者：甘雪婷[1] 黄团新[2] 伍秀珍[1] 朱艳[1] 刘章红[1] 李靖[1] 

机构地区：[1]武警湖北总队医院感染科,武汉430061 [2]武警湖北总队医院医务处,武汉430061

出　　处：《武警医学》2005年第10期751-753,共3页Medical Journal of the Chinese People's Armed Police Force

摘　　要：目的观察硫普罗宁注射液对抗结核药物所致肝损害的治疗作用。方法选取90例因抗结核药物引起肝损害的结核病患者,随机分为两组,治疗组58例,给予硫普罗宁注射液治疗,每次600mg,1/d;对照组32例,不用硫普罗宁注射液治疗,停用抗结核药物。两组所采用的基础治疗相同,疗程均为30d。结果两组治疗前后肝功能比较:治疗组治疗后血清ALT、AST、TBIL下降非常明显,与治疗前相比,差异有统计学意义(P<0.01),两组综合疗效比较,治疗组总有效率明显优于对照组。结论硫普罗宁注射液对抗结核药物所致的肝损害有明显的保护作用。Objective To evaluate the efficaly of tiopronin in treating the liver injury caused by anti - tuberculous drug. Methods Treatment group （58 cases） were given tiopronin injection 600 mg/day for 30 days, without stoping the use of anti - TB drug. Control group （32 cases） were not given tiopronin, with withdrawal of anti- TB drug. The basic therapy of both groups was the same.Results The comparation of the liver function of the two groups before and after treatment： Serum ALT, AST, and TBIL in the treatment group decreased remarkably, with significant difference （ P 〈 0.01）from that before treatment. The therapeutic effect in the treatment group was better than that in the control group. Conclusion Tiopronin has protective effect against liver injury caused by anti - TB drug.

关 键 词：硫普罗宁 抗结核药 药物性肝损害 抗结核药物性肝损害 硫普罗宁注射液 治疗作用 临床疗效观察 治疗前后 结核病患者 血清ALT 治疗组 基础治疗 

分 类 号：R978.3[医药卫生—药品] R977.4[医药卫生—药学]