胰岛素抵抗在大鼠实验性非乙醇性脂肪肝中的作用  

Insulin Resistance in the Pathogenesis of Non-alcoholicFatty Liver Disease

作　　者：吕瑛[1] 徐肇敏[1] 李运红[1] 

机构地区：[1]南京大学附属鼓楼医院消化科,江苏南京210008

出　　处：《江苏大学学报（医学版）》2005年第5期373-376,共4页Journal of Jiangsu University：Medicine Edition

基　　金：江苏省自然科学基金资助项目(BK2003009)

摘　　要：目的:探讨胰岛素抵抗在非乙醇性脂肪肝(NAFLD)中的作用。方法:8只SD大鼠随机分成正常对照组(6只)和高脂饮食组(42只),正常对照组饲养8周,高脂饮食组分为7组,每隔2周处死1组,测定大鼠的体重,肝脏的湿重,空腹真胰岛素(FIns)、血糖(FBG)、血脂水平,观察肝组织学改变。结果:模型组大鼠喂养8周时出现NAFLD。与正常对照组相比,模型组大鼠的FBG,FIns,TG,高密度脂蛋白胆固醇(HDL-C),胰岛素敏感指数(ISI),肝细胞脂肪变程度与对照组相比均有差异。TG,FIns与肝细胞脂肪变程度成正相关,ISI,HDL-C与肝细胞脂肪变程度成负相关。结论:模型组大鼠存在胰岛素抵抗;胰岛素抵抗在非乙醇性脂肪肝的发生中起重要作用。Objective： To explore the effect of insulin resistance on the pathogenesis of non-alcoholic fatty liver disease（NAFLD）. Methods： Forty eight male SD rats were randomly allocated into control group （n = 6 ） fed with standard diet for 8 weeks and model group（ n=42 ） induced by high fat diet. The model group was divided into 7 groups ,these rats were sacrificed at the 2,4,6,8,10,12,14wk of the experiment respectively. Body weight, liver weight, fasting blood glucose （FBG） , serum triglyceride （TG） , fasting serum insulin（Fins） level and liver histology were detected. Results：The livers presented the pathology of hepatocyte steatosis at 8 week in rats of model group. In comparison with the control group, there was difference in FBG, Fins, TG, insulin sensitivity index （ISI）, HDL-C and the degree of fatty liver in model group. TG and Fins were positive correlation with the degree of hepatocyte steatosis. Conclusion ：Insulin resistance generally presents in rats with NAFLD. Insulin resistance may play an important role in the pathogenesis of NAFLD.

关 键 词：胰岛素抵抗 非乙醇性脂肪肝 大鼠 

分 类 号：R587.1[医药卫生—内分泌]