病毒性心肌炎与心肌损害患儿血清抗心磷脂抗体检测的临床意义  

Level of serum ACA and its clinical significance in viral myocarditis and myocardial damage.

作　　者：陆诗祥[1] 朱艳萍[1] 樊敏华[1] 辛珍[1] 郝庆华[1] 秦道刚[1] 

机构地区：[1]聊城市人民医院儿科,山东聊城252000

出　　处：《中国儿童保健杂志》2005年第5期411-413,共3页Chinese Journal of Child Health Care

摘　　要：【目的】探讨抗心磷脂抗体(anticardiolipinantibody,ACA)在病毒性心肌炎(viralmyocarditis,VMC)与心肌损害患儿发病中的作用,以明确VMC与心肌损害的区别。【方法】120例心肌酶增高患儿分为3组,50例VMC患儿、40例上呼吸道感染并心肌损害患儿及30例灭鼠药中毒并心肌损害患儿,采集外周血,采用酶联免疫吸附试验(enzyme-linkedimmunosorbentassay,ELISA)法测定ACA含量。同时测定血清肌钙蛋白I(cardiactroponinI,CTnI)及心肌酶。【结果】VMc组ACA阳性率显著高于心肌损害组(P<0.01),心肌损害两组之间差异无显著性(P>0.05);ACA阳性患儿CTnI平均值显著高于ACA阴性患儿(P<0.05);VMC组ACA升高者,各项心肌酶异常百分数均增高(P<0.05)。【结论】ACA参与VMC的发病,VMC与单纯心肌损害有实质性区别;检测ACA含量有助于VMC与心肌损害的诊断、判断病情和预后。[Objective] To investigate the level of anticardiolipin antibody （ACA） and its significance in viral myocarditis and myocardial damage. [Methods] Blood samples were collected from children with viral myocarditis （VMC） and without VMC. 120 children were divided into two groups： control group （n=70） and VMC group （n=50）, serum levels of ACA and cardiac troponin Ⅰ （CTnⅠ） were measured by enzyme-linked immunosorbent assay （ELISA）. [Results] The rate of ACA-positlve status was significantly higher in children with VMC than that of children with myocardial damage. They were 62 % vs 7.5% （P〈0.01）. There was not significantly increased between two groups of myocardial damage （P〉0.05）. The level of Ctnl was significantly higher in children with ACA-positive status in VMC than in children with ACA-negative status in VMC. They were （0.32±0.03）μg/L vs （0.04±0.01）μg/L （P〈0.05）. [Conclusions] ACA plays an important role in the viral myocarditis.Correlations are found between VMC and myocardial damage. The experiment is helpful for diagnosis and prognosis in viral myocarditis and the myocardial damage.

关 键 词：病毒性心肌炎 心肌损害 儿童 抗心磷脂抗体 

分 类 号：R722.1[医药卫生—儿科]