獐乳对大鼠小肠推进及胃酸、胃蛋白酶分泌影响的实验研究  

Experimental research of RDGLC on the influence to small intestine propulsion, the secretion of gastric fluid acidity and pepsin of rats.

作　　者：闵琛[1] 许春娣[2] 奚容平[2] 刘伟[2] 周莎[2] 张明君[3] 高月锦[3] 

机构地区：[1]上海第二医科大学附属新华医院儿内科,上海200092 [2]上海第二医科大学附属瑞金医院儿内科,上海200025 [3]上海第二医科大学附属瑞金医院动物实验室,上海200025

出　　处：《中国儿童保健杂志》2005年第5期419-421,共3页Chinese Journal of Child Health Care

基　　金：中国科学院上海生命科学研究院与瑞金医院合作项目(2003)

摘　　要：【目的】观察獐乳(RiverDeergastriclumpycontent。RDGLC)对大鼠小肠推进及胃酸、胃蛋白酶分泌的影响。【方法】SD系大鼠,随机分为空白对照组、吗丁啉组和RDGLC不同剂量组,观察各组大鼠小肠推进率、胃液酸度、胃游离酸、总酸度及胃蛋白酶活性情况。【结果】RDGLC0.5mg/(kg·次)以上剂量组对正常大鼠小肠推进有促进作用,且随着剂量的增加,作用逐渐增强;RDGLC高剂量组能促进胃液酸度、游离酸、总酸度分泌,低、中、高剂量组能提高胃蛋白酶活性。【结论】RDGLC具有促小肠动力作用,有利于胃酸分泌及提高胃蛋白酶活性,这可能是其治疗功能性消化不良的药理学基础之一。[Objective] To observe the effect of RDGLC on the ratio of small intestine propulsion,the secretion of gastric fluid acidity and pepsin of the healthy rat. [Methods] Healthy SD rats were divided randomly into saline.domperidone and different doses group of RDGLC. The effect of small intestine propulsion, the secretion of gastric fluid acidity,free acid,total acid and the pepsin were observed in all groups. [Results] The doses over 0.5 mg/（kg·time） of RDGLC could enhance small intestine propulsion;high dose of RDGLC could increase the secretion of gastric fluid acidity, free acid, total acid;low, middle, high dose of ROGLC could promote the activity of pepsin. [Conclusion] ROGLC could promote the motion of small intestine, increase the secretion of gastric fluid acidity and pepsin,which might be one of the pharmacological basis for treating functional dyspepsia.

关 键 词：RDGLC 消化不良 小肠推进 胃酸 胃蛋白酶 

分 类 号：Q95-33[生物学—动物学]