双芳基脲衍生物的合成  

Synthesis of Diarylurea Derivatives

作　　者：冯桂荣[1] 张相平[1] 张会茹[2] 张建维[1] 

机构地区：[1]唐山师范学院化学系,河北唐山063000 [2]唐山市第二十六中学,河北唐山063000

出　　处：《河北化工》2005年第5期34-35,共2页Hebei Chemical Industry

基　　金：河北省教育厅科学研究项目(Z2004465);唐山师范学院科学研究资金项目(02C070301)

摘　　要：脲类化合物所表现出来的优良的生物活性已引起许多科学家的重视,含有—NHCO—基团被认为是抑制酶的活性基本骨架,具有广泛的生物活性。用取代苯胺和苯异氰酸酯反应合成了5个双芳基脲衍生物,对产物进行了元素分析,以红外光谱和氢核磁共振谱确认其结构。Good bioactivities urea have attached the attention of chemical experts. The groups with peptide bond or similar parts are considered as basic framework that can restrain the activities of enzyme. The urea compound containing the ——CONH radicle have the extensive living creature activity.In this thesis, five diarylurea derivatives were synthesized by reacting substituted phenylaniline with isocyanate. IR and HNMR are used to analyze its component element. According to the results ,we can verify its structure and identify.

关 键 词：取代苯胺 双芳基脲衍生物 合成 结构测定 

分 类 号：O626.414[理学—有机化学]