急性胰腺炎患者血清TNF-a和CRP水平的测定及其临床意义  

Clinical significance of serum tumor necrotic factor-a and C reactive protein detections in patients with acute pancreatitis

作　　者：罗心静[1] 谢江文[2] 

机构地区：[1]浙江台州学院医学院,318000 [2]浙江台州市中心医院,318000

出　　处：《江西医学检验》2005年第3期207-208,267,共3页Jiangxi Journal of Medical Laboratory Sciences

摘　　要：目的探讨TNF-a、CRP变化在急性胰腺炎的临床意义。方法测定轻症急性胰腺炎和重型急性胰腺炎患者入院第1、4、7、14天时血清TNF-a和CRP水平,并与健康人对照。结果入院时和入院后重症急性胰腺炎血清TNF-a和CRP水平均高于轻症急性胰腺炎,而后者又均高于健康组(P<0.05),且血清TNF-a含量和CRP含量变化呈正相关(r=0.7124,P<0.05)。结论血清TNF-a和CRP水平变化与AP病情变化密切相关,联合检测有助于了解病情发展。Objective To study the serum levels of tumor necrotic factor-a （ TNF-a ） and C reactive protein （ CRP ） and their significance in patients with acute pancreatitis（AP）. Methods The serum levels of TNF-a and CRP were determined in the patients with moderate acute pancre- atitis（MAP） and severe acute pancreatitis（SAP） of hospitalization at lst,4th,7th, 14th day, and the results were compared with healthy subjects. Results The serum levels of TNF-a and CRP in patients with SAP were significantly higher than those of MAP, and the results of MAP group was significantly higher than that of healthy ones （P〈0.05）. The serum levels of TNF-a and CRP showed positively correlated （r=0.7124,P〈0.05）. Conclusions It suggests that serum levels of TNF-a and CRP are closely correlated with AP and are helpful to predicting the prognosis of acute pancreatitis.

关 键 词：急性胰腺炎 肿瘤坏死因子-A C反应蛋白 

分 类 号：R446.112[医药卫生—诊断学] R657.51[医药卫生—临床医学]