类风湿性关节炎风寒湿痹与风湿热痹动物模型研究  

Study on Rheumatoid Arthritis of Wind-cold-dampnes Type and Wind-heat-dampness Type Bi-Syndrome

作　　者：肖长虹[1] 顾为望[2] 李留洋[3] 郭琳琅[3] 谢卫兵[2] 袁进[2] 郑普德 

机构地区：[1]第一军医大学中医系内科,广州市工业大道510282 [2]第一军医大学实验动物中心 [3]第一军医大学珠江医院 [4]第一军医大学南方医院同位素科

出　　处：《中医杂志》1996年第6期361-365,共5页Journal of Traditional Chinese Medicine

基　　金：广东省自然科学基金

摘　　要：本研究在大鼠胶原诱导性关节炎(CIA)的基础上给予风寒湿、风湿热刺激及葡萄球菌肠毒素B(SEB)外涂。结果显示,单纯风寒湿、风湿热不增加CIA的发病率及炎症积分,也不改变炎症关节的表面温度,但风湿热能显著提高雌性鼠炎症关节的^(99m)Tc含量。在葡萄球菌肠毒素(SEB)外涂时,风寒湿能显著增加雄性鼠的炎症积分(与单纯SEB比较),且显著提高雄性鼠的DTH反应能力(与风湿热比较);风湿热则能显著增加雌性鼠炎症关节的^(99m)Tc含量(与风寒湿比较)。在SEB外涂时,风湿热能显著增加雌性鼠的炎症关节表面温度,但风湿热与风寒湿均显著降低雄性鼠的炎症关节表面温度。The experiment was conducted in rats with CIA on which wind - cold - dampness, wind - heat -dampness stimulation and topical rubbing of SEB were given. Results showed that, wind - cold- dampness or wind - heat - dampness alone didn't increase the incidence of CIA and integration of inflammation, nor change the surface temperature of the affected joint. However, wind -heat -dampness markedly increased the content of 99mTc of affected joint in female rats. When SEC was rubbed on the surface, wind -cold -dampness markedly increases the integration of inflammation in male rats (as compared with pure SEB). and markedly increased the DTH reaction of male rats (as compared with wind -heat- dampness) . Whereas wind - heat dampness markedly increased the content of 99mTc of affected joints in female rats ( as compared with wind - cold - dampness) when topically applied SEB. wind - heat - dampness markedly increased the surface temperature of affected joint in female rats, while wind- heat - dampness and wind - cold - dampness markedly lowered that in the male rats.

关 键 词：类风湿性关节炎 痹证 病理生理学 

分 类 号：R255.602[医药卫生—中医内科学] R259.932.2[医药卫生—中医学]