孟鲁司特片联合布地奈德气雾剂治疗儿童支气管哮喘合并季节性过敏性鼻炎的疗效观察  

The clinical effectiveness of inhaled budesonide combined with oral montelukast versus intranasal budesonide in the treatment of mild to moderate asthma complicated with seasonal allergic rhinitis in children

作　　者：龚放[1] 王成林[1] 黄瑛[1] 邬萍[1] 杨泽凯 

机构地区：[1]雅安市人民医院儿科,四川雅安625000

出　　处：《中国呼吸与危重监护杂志》2005年第5期355-357,共3页Chinese Journal of Respiratory and Critical Care Medicine

摘　　要：目的在合并季节性过敏性鼻炎的轻、中度哮喘儿童中,观察并比较分别用鼻喷布地奈德水溶液联合布地奈德气雾剂与孟鲁司特联合布地奈德气雾剂吸入治疗的临床疗效。方法将合并季节性过敏性鼻炎的轻、中度哮喘儿童随机分为3组:Ⅰ组为布地奈德水溶液鼻喷1个月,同时吸入布地奈德气雾剂6个月;Ⅱ组为孟鲁司特片口服1个月,同时吸入布地奈德气雾剂6个月;Ⅲ组为孟鲁司特片口服3个月,同时吸入布地奈德气雾剂6个月。比较3组儿童鼻炎、哮喘症状体征评分,β2激动剂吸入量以及呼气峰流速(PEFR)值。结果鼻炎、哮喘日间和夜间症状评分在三组间比较无显著性差异;β2激动剂吸入量无显著性差异;PEFR值亦无显著性差异。结论孟鲁司特片联合布地奈德气雾剂治疗儿童支气管哮喘合并季节性过敏性鼻炎,能明显缓解哮喘和鼻炎的症状,减少总的激素用量。Objective To observe the clinical effieaey of inhaled budesonide combined with montelukast or with intranasal budesonide in pediatric asthma subjects complicating with seasonal allergic rhinitis. Methods 78 ehihtren with mild to moderate asthma complicated with seasonal allergic rhinitis were randomly allocated into three groups：intranasal budesnide for 1 month and inhaled budesonide for 6 months;montelukast for 1 month and inhaled budesonide for 6 months; montelukast for 3 months and inhaled budesonide for 6 months. The patients were followed-up for 6 months. Symptom scores of asthma and rhinitis, need for short-acting β2 agonist and peak expiratory, flow rate were recorded. Results After 6 month treatment the daytime and night symptom scores, usage of short-acting β2 agonist and peak flows rate were improved markedly without significant difference among the three treatment groups. Conclusion Our observation suggests that addition-on of montelukast for 1 month to relative low-dose inhaled budesonide can signifieantly eontrol both asthma symptoms and seasonal allergic rhinitis symptoms and improved lung function with relative lower consumption of β2 agonist and steroids.

关 键 词：孟鲁司特片 布地奈德气雾剂 药物治疗 儿童 支气管哮喘 季节性过敏性鼻炎 

分 类 号：R725.6[医药卫生—儿科]