脑室注射催产素对大鼠丘脑束旁核痛反应神经元放电的影响  

Effects of Oxytocin by Intraventricular Injection on Electric Activity of Pain-related Neurons in Nucleus Parafascicularis of Thalamus of Rat

作　　者：李玉荣[1] 张季叶[1] 徐漫莉 岳文杰[2] 

机构地区：[1]哈尔滨医科大学生理学教研室 [2]牡丹江医学院

出　　处：《哈尔滨医科大学学报》1996年第2期103-106,共4页Journal of Harbin Medical University

摘　　要：本文对痛兴奋神经元(PEN)放电减少和痛抑制神经元(PIN)放电增加为镇痛效应,研究了脑室注射不同剂量催产素(OT)对大鼠丘脑束旁核(Pf)中PEN和PIN电活动的影响及作用机制。脑室注射不同剂量OT(0.05U,0.1U,0.2U/10μl)能使Pf中的PEN诱发放电频率出现不同程度的减少,PIN放电抑制时程缩短,有明显的剂量效应关系。OT的镇痛作用可能部分是通过同时影响中枢Pf中PEN和PIN的电活动,从而调制了痛觉信息的接受、传递和处理。The influence and its mechanisms of oxytocin(OT) on pain excitatory neuron (PEN) and pain inhibitatory neuron (PIN) in parafascicularis (Pf) was studied according to the discharging decrease of PEN and the discharging increase of PIN as analgesic effect. We found that the different dosages of OT administered intraventricularly.made electric discharges of PEN decrease in frequency,and shortened inhibitatory duration of electric discharges of PIN in Pf, which appears dose-dependency apparently. The analgesic effect of OT is in part the results of modulating reception,transmission and treatment of pain through influencing simultaneously on electric activity of PEN and PIN in Pf.

关 键 词：催产素 丘脑束旁核 痛兴奋神经元 痛抑制神经元 

分 类 号：R984[医药卫生—药品]