糖皮质激素诱导的体外胸腺细胞凋亡模型的建立  

Apoptosis of Thymocytes Induced by Glucocorticoid in Vitro

作　　者：马春树[1] 姜叙诚[1] 李仁[1] 班翔[1] 朱平[2] 宋雁南[2] 张雅坤[2] 

机构地区：[1]哈尔滨医科大学病理学教研室 [2]哈尔滨医科大学电镜室

出　　处：《哈尔滨医科大学学报》1996年第2期111-112,210,共2页Journal of Harbin Medical University

基　　金：国家自然科学基金;黑龙江省自然科学基金资助课题

摘　　要：在体外培养的大鼠胸腺细胞中加入糖皮质激素,孵育后进行光镜、扫描和透射电镜观察。经激素作用的胸腺细胞发生胞浆和胞核的浓缩,染色质的凝集与裂解和凋亡小体形成等一系列改变,表明了凋亡的形成。Cultured rat thymocytes were treated with glucocorticoid and after incubation the cells were observed with light and electron microscopy. The cells showed a series of morphological changes :shrinkege in volume condensation and fragmentation of chromatin and shedding of apop-totic bodies,indicating the formation of apoptosis.

关 键 词：胸腺细胞 细胞凋亡 糖皮质激素 超微结构 

分 类 号：R329.28[医药卫生—人体解剖和组织胚胎学] R361.3[医药卫生—基础医学]