L—赖氨酸锌在犬体内药代动力学实验研究  

Experimental Studies on Pharmacokinetics of Zinc L-lysinate in Dogs

作　　者：朱志国[1] 贾玉玺[1] 张小云 奚克生[1] 刘巨涛[1] 刘伟明[1] 

机构地区：[1]空军医学高等专科学校

出　　处：《微量元素与健康研究》1996年第1期10-11,共2页Studies of Trace Elements and Health

摘　　要：用原子吸收法测定Ｌ－赖氨酸锌和硫酸锌在大体内血清锌浓度，用一级动力学和一室模型分析Ｌ－赖氨酸锌和硫酸锌的药代动力学基本参数。结果表明，Ｌ－赖氨酸锌的血清锌峰浓度、曲线下面积和相对生物利用度都明显优于硫酸锌，其他各参数两组基本相似，说明Ｌ－赖氨酸锌是一优于硫酸锌的理想补锌药物。Serum zinc conccntration of zinc L-lysinate and zinc sulfdte in dogs are determintld by Atomic Absorption Spectophomctry.basi parameters of pharmacokinetics of zinc L-lysinate and zinc sulfate are analysed by first order roder reaction kinetics and mod-el of,simple in this paper, The results showed the peak of serum zinc concentration ,the area of peak and relative bioavailability of zinc L-lysinate was supeior to zinc sulfate,other bdsic paramaters was similar to the two groups ,this conclusion explained zinc L -lsinate was a better drug to supply trace elements zinc suprior to zinc sulfate.

关 键 词：L-赖氨酸锌 药代动力学 原子吸收法 

分 类 号：R977.4[医药卫生—药品]