昆明鼠围产期使用雷藤氯内酯醇对后代的影响  

EFFECT OF THE T_4 ON OFFSPRINGS OF KUN MING MICE

作　　者：但凌[1] 叶惟三[1] 郭燕[1] 

机构地区：[1]中国医学科学院基础所

出　　处：《解剖学报》1996年第2期209-211,共3页Acta Anatomica Sinica

基　　金：国家计划生育委员会"8.5"攻关课题

摘　　要：用５８只昆明雌鼠，于围产期（孕第１５ｄ至胎鼠出生后１５ｄ）给雌鼠灌服雷藤氯内酯醇（Ｔ＿４）（０．６ｍｇ／ｋｇ／ｄ及０．３ｍｇ／ｋｇ／ｄ），观察了子１代及子２代鼠的出生、生长、发育以及生殖能力。运用行为测试指标测定Ｔ４是否引起后代畸形；采用形态学方法检查胎鼠脏器及骨骼，以判断人是否具有毒性作用及导致畸形。结果表明，子１代及子２代鼠的生长、发育以及生殖能力正常，器官发育正常，运动反射属正常范围；内脏器官未见中毒性病变；胎鼠骨骼发育正常。Fifty -eight female Kun Ming mice were fed with Tripchlorolide(T_4)in Perinatal stage(from 15th day of pregnancy to 21 day after birth).The dosages of T_4 were 0.6mg/kg/d for group 1 and 0.3mg/kg/d for group 2,for 28 days,The results showed that the development and growth of F1 in all groups were normal.The behavioral tests of F1 and F_2 progeny showed that they were normal. The heart、kidney、spleen、skeletal and testis or ovary of F1 were all normal as well.

关 键 词：雷藤氯内酯醇 围产期 小鼠 子代 

分 类 号：R971.1[医药卫生—药品] R714.7[医药卫生—药学]