正常妊娠期间母体左心室收缩功能的变化及其机制探讨  

Change and mechanim of maternal left ventricular systolic function during normal pregnancy

作　　者：南会兰[1] 王长丽[1] 李京艳[1] 王佩显[1] 辛德荣[1] 

机构地区：[1]天津医科大学总医院干部病房,天津300052

出　　处：《中国心血管杂志》2005年第5期359-362,共4页Chinese Journal of Cardiovascular Medicine

摘　　要：目的利用超声心动图揭示正常妊娠期间母体左心室收缩功能的变化并探讨激素作用机制。方法选取试验组107例,正常对照组15例。用超声心动图测量各项指标;检测肾素活性、血管紧张素Ⅱ水平及醛固酮、雌二醇、孕酮水平。结果(1)心排出量于孕早期即开始增快,至孕末期增至最大。(2)各项激素水平随孕期发展均明显增高,且具有一定相关关系。结论左心室本身的收缩功能孕中期略有增强;妊娠期间左心室收缩功能的变化,血压的稳定维持有赖于雌孕激素与肾素血管紧张素系统协同作用,血管紧张素Ⅱ可能增强心肌收缩力。Objective To demonstrate the maternal left ventricular systolic function by echocardiography, measuring the plasma RENIN,ANG Ⅱ and serum ALD,Ea ,PRO to explore their effects on the maternal adaptations. Methods 15 nonpregnant,35 early pregnant,37 second and 35 third trimester normal pregnant women were selected, and blcod was taken to measure the associated hormones. Results 1.CO was increased during pregnancy. 2. Both the RAA system and the steroid hormones were increased throughout the course of normal pregnancy. Conclusion 1. The LV contractility seems to be increased during midpregnancy. 2. The RA system, and PRO, E2 contribute to the maternal hernodyrnamic adaptations, ANGII may increase the LV contractility.

关 键 词：正常妊娠 左心室收缩功能 机制 

分 类 号：R714.1[医药卫生—妇产科学]