降压联合阿托伐他汀治疗对高血压颈动脉粥样硬化的影响  

Effect of antihypertensive treatment combined with artorvastatin on carotid artery atherosclerosis in hypertensive patient

作　　者：郑元琦[1] 陈晓曦[1] 邓水泉[1] 

机构地区：[1]三明市第一医院心内科,福建三明365000

出　　处：《心血管康复医学杂志》2005年第5期475-477,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:探讨降压联合阿托伐他汀治疗对高血压颈动脉粥样硬化的影响。方法:60例高血压患者随机分为阿托伐他汀+常规降压组(A组,32例)及常规降压组(B例,30例)两组。阿托伐他汀用量每天10-20 mg,晚餐时顿服,时间1年。分别观测治疗前、后颈动脉内膜中层厚度(IMT)、TC、TG、HDL-C、LDL-C、高敏C反应蛋白(hsCRP)含量的变化。结果:治疗后A组颈动脉TMI值缩小,血中TC、TG、LDL-C浓度下降,HDL-C浓度上升, hsCRP水平降低(P均<0.01),B组变化无显著性差异(P>0.05),两组间比较也有显著性差异(P<0.05-< 0.01)。结论:常规降压联合阿托伐他汀治疗具有逆转颈动脉粥样硬化的作用。Objective： To study the effect of antihypertensive treatment combined with atorvastatin on carotid artery artherosclerosis in hypertensive patient. Methods ： The 62 hypertensive patients were randomly divided into routine antihypertensive treatment combined with atorvastatin group （group A, n=32） and routine antihypertensive treatment group （group B, n= 30）. The patients in A group received atorvastatin 10-20 mg every night for 1 year. Intima-media thickness （IMT） of carotid artery. TC. TG. HDL-C. LDL-C. high sensitivity C reactive protein （hsCRP） were determind before and after treatment. Results： The IMT of carotid artery, TC, TG, LDL-C. hsCRP decreased significantly （P〈0.01）, HDL-C significantly increased （P〈0. 01） in A group after 1 year. While in group B, those indexes were not significantly different （P〉0. 05）. Compared with A group, they had significantly different （P〈0. 05-〈0. 01）. Conclusion： Routine antihypertensive treatmant combined with atorvastatin can reverse carotid artery artherosclerosis in hypertensive patient.

关 键 词：阿托伐他汀 颈动脉 高脂血症 C反应蛋白质 

分 类 号：R544.1[医药卫生—心血管疾病]