红景天对高原去势大鼠骨质疏松症的血清IL-6和TNF-α含量的影响  

Effect of Rhodiola on Serum Level of IL-6 and TNF-α in Castrated Rats with Osteoporosis at High Altitude

作　　者：白孟海[1] 葛宝丰[1] 田泉[2] 高文魁[3] 郑荣[1] 王琦[1] 

机构地区：[1]兰州军区兰州总医院骨科研究所,730050 [2]兰州医学院第一附属医院,730000 [3]西宁解放军第四医院,81001

出　　处：《高原医学杂志》2005年第3期15-17,共3页Journal of High Altitude Medicine

摘　　要：目的:探讨红景天对高原去势大鼠血清白细胞介素6(IL-6)和肿瘤坏死因子(TNF-α)的影响及红景天抗高原组织缺氧和预防高原骨质疏松症的效果。方法:本实验在高原建立了切除卵巢诱发绝经后骨质疏松症Wistar大鼠模型,分为A组(假手术或正常组),B组(切除卵巢组),C组(切除卵巢+尼尔雌醇组),D组(切除卵巢+红景天混合饲料组),E组(切除卵巢+红景天浸液组)。术后置海拔3100m高原饲养3个月后,测定血清IL-6和TNF-α含量,观察红景天对高原去势大鼠骨质疏松症的预防作用。结果:术后3个月,A组、C组、D组和E组IL-6和TNF-α血清含量均显著低于B组。结论:红景天能降低体内血清IL-6和TNF-α含量,具有抑制骨吸收促进骨形成的作用。Objeαive ：To study changes of level of IL - 6 and TNF - α in the castrated rates and effeα of rhodiola on these changes at high altitude to against hypoxia and prevent the osteoporosis. Methods： The rats＇ models were built by ophorotomy. A total of rats were assigned in the group A （ normal group）, the group B （ oophorotomy group）, the group C （ oophorotomy ＋ nilestrol group）, the group D （ oophorotomy ＋ rhodiola breed group） and group E （ oophorotomy ＋ rhodiola extraα group） respeαively. The level of IL - 6 and TNF - α were measured after three months castrate and the status of osteoporosis was observed. Results： The level of IL-6 and TNF -α in the group A, C, D and E was significantly lower than that in the group B. Conclusions： The rhodiola can decrease the serum level of IL - 6 and TNF - α and increase the effeα of osteosis at high altitude.

关 键 词：高原 IL-6 TNF-Α 红景天 骨质疏松 绝经后 

分 类 号：R285[医药卫生—中药学]