碘缺乏对大鼠神经元特异性烯醇化酶基因表达的影响  

The expression of NSE gene in the iodine-deficient rat

作　　者：宋建良[1] 赵崇[1] 宋学文[1] 蔡军[1] 陈祖培[1] 张镜宇[1] 

机构地区：[1]天津医科大学内分泌研究所,300070

出　　处：《中国地方病学杂志》1996年第3期129-131,共3页Chinese Jouranl of Endemiology

基　　金：此课题为天津市21世纪青年科学资金资助

摘　　要：以 NSE 的 cDNA 制备基因探针,用 Northern blot 方法检测 NSE mRNA 的相对含量,观察碘缺乏(甲低)对大鼠 NSE 基因表达的影响,结果表现1日龄和20日龄低碘甲低大鼠 NSE mRNA 含量均低于同龄正常大鼠,表明低碘甲低可于转录水平阻碍 NSE 的基因表达。The NSE gene probe was prepared from NSE cDNA and the effect of iodine-deficlency (hypothyroid)on the NSE gene expression in rats was studied by means of analysing the relative con- tent of NSE mRNA with Northern blot.It was found that the contents of NSE mRNA were lower in iodine-deficient(hypothyroid)rats of both 1 and 20 days of age than those in normal rats of the same age.It might suggest that iodine-deficiency(hypothyroid)could block the NSE gene expression in tran- scriptional level.

关 键 词：烯醇化酶 碘缺乏 基因表达 NSE 甲状腺机能减退 

分 类 号：R591.1[医药卫生—内科学] R581.2[医药卫生—临床医学]